ReviewJournal of lipid and atherosclerosis2021
Impact of Obesity-Related Inflammation on Cardiac Metabolism and Function.
Review in Journal of lipid and atherosclerosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Effect of a Wearable Device-Based Physical Activity Intervention in North Korean Refugees: Pilot Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- Rethinking cardiometabolic therapy thresholds in individuals with obesity.International journal of obesity (2005) · 2026Review
- Tirzepatide and risk of newly diagnosed aortic stenosis in patients with obesity: a multi-institutional real-world cohort study.BMC cardiovascular disorders · 2026Article
- Reversible left ventricular trabecular remodeling after bariatric surgery in obesity: a prospective cohort study using quantitative cardiac MRI.Quantitative imaging in medicine and surgery · 2026Article
- Exploring the relationship between reproductive aging, arterial stiffness, and cardiorespiratory fitness in women after menopause.Physiological reports · 2026Article
- Beyond BMI: L4-L5 visceral-to-subcutaneous fat ratio on CT predicts impaired wound healing after posterior lumbar fusion-A retrospective study.Frontiers in surgery · 2026Article
- A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study.Frontiers in cardiovascular medicine · 2026Article
- The Impact of Cardio-Renal-Metabolic Profile in Dilated Cardiomyopathy.Current cardiology reports · 2025Review
- Aerobic Exercise Modulates Lipo-Toxicity Genes Expression in Cardiac Tissue of Obese Rats Induced with High-Fat and Fructose Diet.Advanced biomedical research · 2025Article
- Recent Glycemia Is a Major Determinant of β-Cell Function in Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2024Article
- Cardiometabolic benefits of fenofibrate in heart failure related to obesity and diabetes.Cardiovascular diabetology · 2024Article
- Association of Body Mass Index with Outcomes in Patients with Heart Failure with Reduced Ejection Fraction (HFrEF).Nutrients · 2024Article
- Article
- Dietary lipids shape cytokine and leptin profiles in obesity-metabolic syndrome implications: A cross-sectional study.PloS one · 2024Article
- Metabolic Approaches for the Treatment of Dilated Cardiomyopathy.Journal of cardiovascular development and disease · 2023Review
- Adipokines at the crossroads of obesity and mesenchymal stem cell therapy.Experimental & molecular medicine · 2023Review
- Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling.Acta pharmacologica Sinica · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review focuses on the role of adipose tissue in obese individuals in the development of metabolic diseases, and their consequences for metabolic and functional derangements in the heart. The general idea is that the expansion of adipocytes during the development of obesity gives rise to unhealthy adipose tissue, characterized by low-grade inflammation and the release of proinflammatory adipokines and fatty acids (FAs). This condition, in turn, causes systemic inflammation and elevated FA concentrations in the circulation, which links obesity to several pathologies, including impaired insulin signaling in cardiac muscle and a subsequent shift in myocardial substrate oxidation in favor of FAs and reduced cardiac efficiency. This review also argues that efforts to prevent obesity-related cardiometabolic disease should focus on anti-obesogenic strategies to restore normal adipose tissue metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.