ArticleJournal of oral biology and craniofacial research
Retinoic and ascorbic acids induce osteoblast differentiation from human dental pulp mesenchymal stem cells.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Induction of Mesenchymal Stem Cell and Preosteoblast Differentiation: A Comparative Study Between Conditioned Medium and In Vitro Coculture.International journal of dentistry · 2026Article
- Regenerative teeth induced by in vitro mesenchymal cells in mice via repressing BMP4 and activating retinoic acid/osteopontin.Cell regeneration (London, England) · 2025Article
- Antioxidant Materials in Oral and Maxillofacial Tissue Regeneration: A Narrative Review of the Literature.Antioxidants (Basel, Switzerland) · 2023Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have suggested an important role of retinoic acid (RA) and ascorbic acid (AA) in the stimulation of osteoblastic differentiation; however, the function of RA and AA in the osteogenic differentiation from human dental pulp (hDPSCs) remains unclear.
objectiveThis
methodshDPSCs were treated with different doses of RA and AA, separately or in combination (RA + AA). Morphology and cell proliferation were assessed. Osteoblast differentiation was evaluated by alizarin red, alkaline phosphatase staining, and
resultsA significant reduction was observed in the number of cells treated with RA (26%) and RA + AA (30%) after 12 days of treatment. AA treatment alone induced a 12% reduction in the number of cells. Morphologically, the cells treated with RA and RA + AA were larger and more elongated than the control cells. A mesh pattern was observed in cells treated with AA. Numerous calcified nodules were present in cells treated with RA, AA, and RA + AA. This coincided with increased expression of
conclusionshDPSCs treated with RA and RA + AA showed significant reduction in proliferation, detectable morphological changes, and expression of the key differentiation gene
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Registered trials
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