ArticleBiomicrofluidics2021
Dual-fiber microfluidic chip for multimodal manipulation of single cells.
Article in Biomicrofluidics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Acousto-optogenetics bandpass stabilizer: A programmable platform for mapping single-cell phenotypic life trajectories.Materials today. Bio · 2025Article
- Label-free spatiotemporal decoding of single-cell fate via acoustic driven 3D tomography.Materials today. Bio · 2024Article
- A vibrating capillary for ultrasound rotation manipulation of zebrafish larvae.Lab on a chip · 2024Article
- High-Efficiency Single-Cell Electrical Impedance Spectroscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On-chip single-cell manipulation is imperative in cell biology and it is desirable for a microfluidic chip to have multimodal manipulation capability. Here, we embedded two counter-propagating optical fibers into the microfluidic chip and configured their relative position in space to produce different misalignments. By doing so, we demonstrated multimodal manipulation of single cells, including capture, stretching, translation, orbital revolution, and spin rotation. The rotational manipulation can be in-plane or out-of-plane, providing flexibility and capability to observe the cells from different angles. Based on out-of-plane rotation, we performed a 3D reconstruction of cell morphology and extracted its five geometric parameters as biophysical features. We envision that this type of microfluidic chip configured with dual optical fibers can be helpful in manipulating cells as the upstream process of single-cell analysis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.