Evidence map›Paper›PMID 33537084›Full record

ArticleTheranostics2021

Large-scale tumor-associated collagen signatures identify high-risk breast cancer patients.

Gangqin Xi, Wenhui Guo, Deyong Kang, Jianli Ma, Fangmeng Fu, Lida Qiu, Liqin Zheng, Jiajia He, Na Fang, Jianhua Chen and 9 more

Abstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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  18. The Duality of Collagens in Metastases of Solid Tumors.International journal of molecular sciences · 2025
    Review
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Gangqin XiKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Wenhui GuoBreast Surgery Ward, Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Deyong KangDepartment of Pathology, Fujian Medical University Union Hospital, Fuzhou, China.
Jianli MaDepartment of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Fangmeng FuBreast Surgery Ward, Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Lida QiuKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Liqin ZhengKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Jiajia HeKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Na FangKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Jianhua ChenKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Jingtong LiDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Shuangmu ZhuoKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Xiaoxia LiaoNational Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, USA.
Haohua TuBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, USA.
Lianhuang LiKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.
Qingyuan ZhangDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Chuan WangBreast Surgery Ward, Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Stephen A BoppartBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, USA.
Jianxin ChenKey Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, China.

Funding

Imaging tumor microenvironment by Optical Fiber-Tethered Simultaneous Lifetime-resolved Autofluorescence-Multiharmonic (OFT-SLAM) microscopyR01CA241618 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A, TU, HAOHUA · 2019 to 2022
$1.6M
Fiber-Delivered Programmable Supercontinuum Laser Adaptive to EvolvingNeurophotonic Research R43MH119979 · NIMH · LIVEBX, LLC · PI DURACK, MATTHEW, LLANO, DANIEL A · 2019 to 2020
$878k
Correlative nonvital standard histopathology and vital multiphoton prehistopathologyR41GM139528 · NIGMS · LIVEBX, LLC · PI TU, HAOHUA · 2020 to 2020
$156k
NCI NIH HHS R01 CA241618NIGMS NIH HHS R41 GM139528NIMH NIH HHS R43 MH119979
6 · The paper itself

Abstract

The notion of personalized medicine demands proper prognostic biomarkers to guide the optimal therapy for an invasive breast cancer patient. However, various risk prediction models based on conventional clinicopathological factors and emergent molecular assays have been frequently limited by either a low strength of prognosis or restricted applicability to specific types of patients. Therefore, there is a critical need to develop a strong and general prognosticator.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsCohort StudiesCollagenDisease-Free SurvivalFemaleGene Expression ProfilingHumansMicroscopy, Fluorescence, MultiphotonMiddle AgedNomogramsPrognosisProgression-Free SurvivalBiomarkers, TumorCollagenBreast cancerdisease-free survivalmultiphoton imagingtumor-associated collagen signatures

Identifiers

PMID33537084
PMCPMC7847696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.