Evidence map›Paper›PMID 33537078›Full record

ArticleTheranostics2021

Conditioned medium from adipose-derived stem cells attenuates ischemia/reperfusion-induced cardiac injury through the microRNA-221/222/PUMA/ETS-1 pathway.

Tzu-Lin Lee, Tsai-Chun Lai, Shu-Rung Lin, Shu-Wha Lin, Yu-Chen Chen, Chi-Ming Pu, I-Ta Lee, Jaw-Shiun Tsai, Chiang-Wen Lee, Yuh-Lien Chen

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
    Pooled it
  2. Article
  3. Interplay between ischemia-reperfusion and metabolic reprogramming.Apoptosis : an international journal on programmed cell death · 2026
    Review
  4. ETS‑1/ETS‑2 transcription factors in CVD (Review).International journal of molecular medicine · 2026
    Review
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Tzu-Lin LeeDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Tsai-Chun LaiDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Shu-Rung LinDepartment of Bioscience Technology, College of Science, Chung-Yuan Christian University, Taoyuan, Taiwan.
Shu-Wha LinDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yu-Chen ChenDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chi-Ming PuDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Jaw-Shiun TsaiDepartment of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chiang-Wen LeeDepartment of Nursing, Division of Basic Medical Sciences, and Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan.
Yuh-Lien ChenDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
National Taiwan University · TWChung Yuan Christian University · TWChiayi Chang Gung Memorial Hospital · TWNational Taiwan University Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adipose TissueAnimalsApoptosisApoptosis Regulatory ProteinsCell DeathCulture Media, ConditionedFibrosisMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMice, KnockoutMicroRNAsMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumApoptosis Regulatory ProteinsCulture Media, ConditionedEts1 protein, mouseMicroRNAsMIRN221 microRNA, mouseMIRN222 microRNA, mouseProto-Oncogene Protein c-ets-1PUMA protein, mouseTumor Suppressor ProteinsADSC-CMapoptosisfibrosisIschemia/reperfusion injurymiR-221/222

Identifiers

PMID33537078
PMCPMC7847683
OpenAlexW3118609716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.