Evidence map›Paper›PMID 33537031›Full record

ArticleFrontiers in immunology2020

Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis.

Jimmy Y Song, J Daniel Griffin, Nicholas R Larson, Matthew A Christopher, C Russell Middaugh, Cory J Berkland

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jimmy Y SongDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, United States.
J Daniel GriffinDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, United States.
Nicholas R LarsonDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, United States.
Matthew A ChristopherDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, United States.
C Russell MiddaughDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, United States.
Cory J BerklandDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, United States.
University of Kansas · US

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
PHARMACEUTICAL ASPECTS OF BIOTECHNOLOGY TRAININGT32GM008359 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI SIAHAAN, TERUNA J., VOLKIN, DAVID · 1989 to 2018
$5.0M
NIGMS NIH HHS P20 GM113117NIGMS NIH HHS T32 GM008359
6 · The paper itself

Abstract

A synthetic peptide, K-PLP, consisting of 11-unit poly-lysine (K11) linked

Indexed as

Molecular MimicryAnimalsAutoantigensCells, CulturedEncephalomyelitis, Autoimmune, ExperimentalFemaleGlatiramer AcetateImmunosuppressive AgentsInjections, SubcutaneousLymph NodesMicePeptidesProtein AggregatesSpleenTissue DistributionAutoantigensGlatiramer AcetateImmunosuppressive AgentsPeptidesProtein AggregatesCopaxone®EAEglatiramer acetatemultiple sclerosispoly-lysineSC injection simulation

Identifiers

PMID33537031
PMCPMC7848024
OpenAlexW3124040363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.