Evidence map›Paper›PMID 33537021›Full record

ArticleFrontiers in microbiology2020

Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit

Luiz A E Pollo, Erlon F Martin, Vanessa R Machado, Daire Cantillon, Leticia Muraro Wildner, Maria Luiza Bazzo, Simon J Waddell, Maique W Biavatti, Louis P Sandjo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Polyacetylenes as antibacterial, antibiofilm, and anti-quorum-sensing agents: Sources, chemistry, bioactivities, andSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Luiz A E PolloPrograma de Pós-Graduação em Farmácia, CCS, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Erlon F MartinPrograma de Pós-Graduação em Farmácia, CCS, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Vanessa R MachadoPrograma de Pós-Graduação em Farmácia, CCS, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Daire CantillonDepartment of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.
Leticia Muraro WildnerDepartment of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.
Maria Luiza BazzoPrograma de Pós-Graduação em Farmácia, CCS, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Simon J WaddellDepartment of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.
Maique W BiavattiPrograma de Pós-Graduação em Farmácia, CCS, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Louis P SandjoPrograma de Pós-Graduação em Química, CFM, Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Universidade Federal de Santa Catarina · BRUniversity of Sussex · GBBrighton and Sussex Medical School · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Drug-resistant tuberculosis threatens to undermine global control programs by limiting treatment options. New antimicrobial drugs are required, derived from new chemical classes. Natural products offer extensive chemical diversity and inspiration for synthetic chemistry. Here, we isolate, synthesize and test a library of 52 natural and synthetic compounds for activity against

Indexed as

antimicrobial drug resistancedrug discoveryMycobacterium tuberculosisnatural productsynthetic polyacetylenes

Identifiers

PMID33537021
PMCPMC7847937
OpenAlexW3121768721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.