Evidence map›Paper›PMID 33537002›Full record

ReviewFrontiers in endocrinology2020

Control of Bone Matrix Properties by Osteocytes.

Amy Creecy, John G Damrath, Joseph M Wallace

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Evaluation ofPeerJ · 2024
    Pooled it
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  7. Rethinking osteocyte modelsFrontiers in bioengineering and biotechnology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amy CreecyDepartment of Biomedical Engineering, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, United States.
John G DamrathWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.
Joseph M WallaceDepartment of Biomedical Engineering, Indiana University-Purdue University at Indianapolis, Indianapolis, IN, United States.
Indiana University – Purdue University Indianapolis · USPurdue University West Lafayette · US

Funding

Comprehensive Training Program in Musculoskeletal ResearchT32AR065971 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ALEXANDER G ROBLING · 2015 to 2026
$4.4M
Targeting collagen as an interventional approach to improve bone material propertiesR01AR072609 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI WALLACE, JOSEPH MICHAEL · 2018 to 2022
$1.7M
Interdisciplinary Bioengineering Training in Diabetes ResearchT32DK101001 · NIDDK · PURDUE UNIVERSITY · PI EVANS-MOLINA, CARMELLA, VOYTIK-HARBIN, SHERRY L · 2013 to 2022
$1.6M
The Effect of Etelcalcetide on Bone-tissue Properties in End Stage Kidney DiseaseF30DK121399 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAMRATH, JOHN · 2019 to 2023
$256k
NIAMS NIH HHS R01 AR072609NIAMS NIH HHS T32 AR065971NIDDK NIH HHS F30 DK121399NIDDK NIH HHS T32 DK101001
6 · The paper itself

Abstract

Osteocytes make up 90-95% of the cellular content of bone and form a rich dendritic network with a vastly greater surface area than either osteoblasts or osteoclasts. Osteocytes are well positioned to play a role in bone homeostasis by interacting directly with the matrix; however, the ability for these cells to modify bone matrix remains incompletely understood. With techniques for examining the nano- and microstructure of bone matrix components including hydroxyapatite and type I collagen becoming more widespread, there is great potential to uncover novel roles for the osteocyte in maintaining bone quality. In this review, we begin with an overview of osteocyte biology and the lacunar-canalicular system. Next, we describe recent findings from

Indexed as

Bone RemodelingHomeostasisOsteogenesisAnimalsBone MatrixHumansMineralsOsteocytesMineralscollagenextracellular matrixlacunocanalicular networkmechanical loadingmineralperilacunar remodeling

Identifiers

PMID33537002
PMCPMC7848033
OpenAlexW3125968369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.