Trial reportFrontiers in endocrinology2020
Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome.
Trial report in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Comparative Outcomes of Letrozole Versus Clomiphene Citrate for Ovulation Induction in Patients With PCOS: Systematic Review and Meta-Analysis.JBRA assisted reproduction · 2026Pooled it
- Letrozole and clomiphene versus letrozole alone for ovulation induction in women with PCOS: a systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Pooled it
- The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis.Reproductive biology and endocrinology : RB&E · 2023Pooled it
- Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artificial cycle for endometrial preparation prior to frozen embryo transfer in women with polycystic ovary syndrome.Reproductive biology and endocrinology : RB&E · 2022Pooled it
- The Dose-Related Efficacy of Acupuncture on Endometrial Receptivity in Infertile Women: A Systematic Review and Meta-Analysis.Frontiers in public health · 2022Pooled it
- Letrozole ovulation regimen for frozen-thawed embryo transfer in women with polycystic ovary syndrome: a muti-centre randomised controlled trial.Reproductive biology and endocrinology : RB&E · 2025Trial
- Letrozole-stimulated cycles versus hormone replacement treatment cycles for frozen embryo transfer in women with polycystic ovary syndrome: a prospective randomized controlled trial.Journal of assisted reproduction and genetics · 2025Trial
- Investigation of the effects of recombinant and urinary FSH used for ovulation induction on pregnancy results in an experimental animal model in terms of endometrial receptivity markers.BMC pregnancy and childbirth · 2026Article
- Acupuncture for ovulation induction in polycystic ovary syndrome: study protocol for a multicenter, randomized, sham-controlled trial.Frontiers in endocrinology · 2026Article
- Gonadotropin Releasing Hormone-Antagonist Protocol (GnRH-ant) Combined Letrozole (LE) for Expected High Ovarian Responders (HOR): a Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Impact of different endometrial preparation protocols on pregnancy outcomes in patients at high risk for ovarian hyperstimulation syndrome: a propensity score matched retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Ongoing Clinical Trials for Polycystic Ovarian Syndrome (PCOS) Afflicted Infertility in Women: A Narrative Review.Reviews on recent clinical trials · 2025Review
- Review
- Impact of letrozole co-treatment in an antagonist protocol for IVF/ICSI: a retrospective study.Reproductive biology and endocrinology : RB&E · 2024Article
- Strong Early Impact of Letrozole on Ovulation Induction Outperforms Clomiphene Citrate in Polycystic Ovary Syndrome.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- The use of propensity score matching to assess the effectiveness of the endometrial receptivity analysis in patients with recurrent implantation failure.Frontiers in endocrinology · 2024Article
- Follicular development and endometrial receptivity of different androgen phenotypes in women with polycystic ovary syndrome.Frontiers in endocrinology · 2024Article
- Hormonal and Metabolic Factors Influence the Action of Progesterone on the Endometrium of Women with Polycystic Ovary Syndrome.Diagnostics (Basel, Switzerland) · 2023Article
- The regulatory effects of clomiphene and tamoxifen on mTOR and LC3-II expressions in relation to autophagy in experimental polycystic ovary syndrome (PCOS).Molecular biology reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Numerous studies have reported on ovulation and pregnancy rates in patients with polycystic ovary syndrome (PCOS). However, relevant data on endometrial receptivity are limited. This study was conducted to compare endometrial receptivity during implantation windows among letrozole (LE), clomiphene citrate (CC), and natural cycle, and to assess the predictive value for pregnancy of observed indicators. Methods: This randomized controlled trial study enrolled 270 patients with PCOS. Patients were given LE (n=90) at a dose of 2.5mg/day or CC (n=90) at a dose of 50 mg/day on cycle days 5-9 for ovulation induction. Patients in the natural cycle group (n=90) did not receive any drug for ovulation induction. Endometrial ultrasonic parameters, integrin αvβ3, and vascular endothelial growth factor (VEGF) concentrations in uterine secretion were detected during the implantation window. The endometrial receptivity, ovulation rate, pregnancy rates, and predictive value of observed indicators for pregnancy were analyzed. Results: The successful ovulation rate did not differ between the LE group and CC group ( Conclusions: Endometrial receptivity during the implantation window of LE is superior to CC in PCOS women, which may be related to higher clinical pregnancy and ongoing pregnancy rates. Endometrial FI examined by 3-D power Doppler, and integrin αvβ3 in uterine secretion during the implantation window, could be preferable non-invasive predictor markers for pregnancy. Clinical Trial Registration: www.chictr.org.cn, ChiCTR1900023423.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.