Evidence map›Paper›PMID 33536949›Full record

ArticleFrontiers in psychiatry2020

Aging as a Context for the Role of Inflammation in Depressive Symptoms.

Kelci Straka, Mai-Lan Tran, Summer Millwood, James Swanson, Kate Ryan Kuhlman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  9. Social support and aging: psychometric analysis of the ENRICHD Social Support Instrument in a Chilean population over 50.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2025
    Article
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  11. Review
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  14. Review
  15. Article
  16. Inflammaging and Cannabinoids.Ageing research reviews · 2021
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kelci StrakaDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
Mai-Lan TranDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
Summer MillwoodDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
James SwansonDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
Kate Ryan KuhlmanDepartment of Psychological Science, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
WIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009
$6.9M
Midlife Health in Japan (MIDJA) and the U.S. (MIDUS)R37AG027343 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2007 to 2016
$5.9M
Behavioral and inflammatory responses to stress: Implications for depression in youth exposed to adversityK08MH112773 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUHLMAN, KATE RYAN · 2017 to 2021
$862k
NCATS NIH HHS UL1 TR002373NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR023942NCRR NIH HHS UL1 RR025011NIA NIH HHS P01 AG020166NIA NIH HHS R37 AG027343NIA NIH HHS U19 AG051426NIMH NIH HHS K08 MH112773
6 · The paper itself

Abstract

Inflammation has been implicated in the pathogenesis and maintenance of depressive symptoms. The role of inflammation in depressive symptomatology may be complex, varying within endophenotypes and across the lifespan. Aging is associated with myriad changes in the structure and function of the brain. Yet, little attention has been given to the role of inflammation in depressive symptoms within a lifespan developmental framework. In this study, we examined whether the association between inflammation and depressive symptom domains varied by age. Participants were a community sample of individuals (

Indexed as

aginganhedoniadepressionimmune systeminflammationlifespansomatic complaints

Identifiers

PMID33536949
PMCPMC7848015
OpenAlexW3123438733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.