ReviewFrontiers in physiology2020
Cerebrovascular Reactivity Mapping Without Gas Challenges: A Methodological Guide.
Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniquesJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Pooled it
- The acute influence of amateur boxing on dynamic cerebral autoregulation and cerebrovascular reactivity to carbon dioxide.European journal of applied physiology · 2024Trial
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- The Arlington study of healthy aging: a multidisciplinary community cohort study of functional decline with age.GeroScience · 2026Article
- Hypoxia-targeted BOLD MRI signal heterogeneity as a complementary metric for glioblastoma characterization: a pilot study.Journal of neuro-oncology · 2026Article
- Age differences in spontaneous cerebrovascular reactivity at rest.GeroScience · 2026Article
- Respiration Can Trigger Cerebrovascular Reactivity: A Novel Method to Quantify Cerebrovascular Resistance Dynamics Using Real-Time Phase-Contrast MRI.Magnetic resonance in medicine · 2026Article
- Functional Magnetic Resonance Imaging Signal Typically Viewed as "Noise" Has Clinical Relevance in Psychiatry.Biological psychiatry global open science · 2026Article
- Cerebrovascular Reactivity Assessment with Breath-Hold Functional MRI in Patients with Moyamoya Angiopathy: Which Time Period to Analyze?Diagnostics (Basel, Switzerland) · 2026Article
- The Relationship Between Hippocampal Cerebrovascular Reactivity and Brain Structure in Older Age.Human brain mapping · 2026Article
- Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke.bioRxiv : the preprint server for biology · 2026Article
- Iterative delay correction improves breath-hold cerebrovascular reactivity mapping in clinical populations.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Evaluation of cerebrovascular reactivity impairment using resting-state BOLD MRI in symptomatic patients with unilateral intracranial artery occlusion.Cerebral circulation - cognition and behavior · 2026Article
- Neurophysiological mechanisms of breathing-based well-being practices: a narrative review for clinical application.Frontiers in psychiatry · 2026Review
- Using ECG-derived respiration for explaining BOLD-fMRI fluctuations during rest and respiratory modulations.Scientific reports · 2025Article
- Cerebrovascular reactivity metrics as predictors of cognitive performance in healthy ageing: insights from transcranial colour-coded ultrasound.The ultrasound journal · 2025Article
- MRI mapping of hemodynamics in the human spinal cord.Scientific reports · 2025Article
- Systemic physiological "noise" in fMRI has clinical relevance.medRxiv : the preprint server for health sciences · 2025Article
- Assessing and Improving the Reproducibility of Cerebrovascular Reactivity Evaluations in Healthy Subjects Using Short-Breath-Hold fMRI.Diagnostics (Basel, Switzerland) · 2025Article
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cerebrovascular reactivity (CVR) is defined as the ability of vessels to alter their caliber in response to vasoactive factors, by means of dilating or constricting, in order to increase or decrease regional cerebral blood flow (CBF). Importantly, CVR may provide a sensitive biomarker for pathologies where vasculature is compromised. Furthermore, the spatiotemporal dynamics of CVR observed in healthy subjects, reflecting regional differences in cerebral vascular tone and response, may also be important in functional MRI studies based on neurovascular coupling mechanisms. Assessment of CVR is usually based on the use of a vasoactive stimulus combined with a CBF measurement technique. Although transcranial Doppler ultrasound has been frequently used to obtain global flow velocity measurements, MRI techniques are being increasingly employed for obtaining CBF maps. For the vasoactive stimulus, vasodilatory hypercapnia is usually induced through the manipulation of respiratory gases, including the inhalation of increased concentrations of carbon dioxide. However, most of these methods require an additional apparatus and complex setups, which not only may not be well-tolerated by some populations but are also not widely available. For these reasons, strategies based on voluntary breathing fluctuations without the need for external gas challenges have been proposed. These include the task-based methodologies of breath holding and paced deep breathing, as well as a new generation of methods based on spontaneous breathing fluctuations during resting-state. Despite the multitude of alternatives to gas challenges, existing literature lacks definitive conclusions regarding the best practices for the vasoactive modulation and associated analysis protocols. In this work, we perform an extensive review of CVR mapping techniques based on MRI and CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.