ReviewFrontiers in cellular neuroscience2020
From Maternal Diet to Neurodevelopmental Disorders: A Story of Neuroinflammation.
Review in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Mapping evidence on maternal metabolic conditions and child neurodevelopment in the Caribbean: a scoping review.Frontiers in nutrition · 2026Pooled it
- Impacts of Consumption of Ultra-Processed Foods on the Maternal-Child Health: A Systematic Review.Frontiers in nutrition · 2022Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Review
- Nutritional Approaches to Managing Brain Fog: Insights Into Neuroinflammation, the Gut-brain Axis, and Sleep.Current nutrition reports · 2026Review
- Maternal pre-pregnancy body mass index, gestational weight gain and epilepsy in the offspring: A population-based cohort study.Epilepsy research · 2026Article
- Correction: Implications for the Prevention of Poverty-Related Environmental Risks for Childhood ADHD: A Narrative Review.Child psychiatry and human development · 2026Article
- Maternal high-fat diet exposure is associated with altered hypothalamic microglial development and reduced early postnatal TGFβ1 signaling in male offspring.Frontiers in endocrinology · 2026Article
- Exploring the relationship between maternal carbohydrate quality and quantity during pregnancy and early childhood neurodevelopment: a prospective cohort study within the BiSC cohort.European journal of nutrition · 2025Article
- Gut Microbiota and Autism: Unlocking Connections.Nutrients · 2025Review
- Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study.Translational psychiatry · 2025Article
- Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development.Healthcare (Basel, Switzerland) · 2025Review
- Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale.Autism research : official journal of the International Society for Autism Research · 2025Article
- Association of Prenatal Healthy and Unhealthy Plant-Based Diets with Behavioral Outcomes in Preschool Children.Nutrients · 2025Article
- Identification of immune cells and circulating inflammatory factors associated with neurodevelopmental disorders by bidirectional Mendelian randomization and mediation analysis.Scientific reports · 2025Article
- Lactobacillus paracasei-derived extracellular vesicles reverse molecular and behavioral deficits in mouse models of autism spectrum disorder.Experimental & molecular medicine · 2025Article
- Disrupted fetal carbohydrate metabolism in children with autism spectrum disorder.Journal of neurodevelopmental disorders · 2025Article
- Higher prenatal dietary glycemic index in the third trimester of pregnancy is associated with infant negative affect at 6 months.Scientific reports · 2025Article
- Dietary glycemic index and load during pregnancy and offspring behavioral outcomes: exploring sex differences.European journal of pediatrics · 2025Observational
- Building blocks of life: improving nutrition and health outcomes through fortification and breastfeeding in the first 1000 days of a child's life.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Providing the appropriate quantity and quality of food needed for both the mother's well-being and the healthy development of the offspring is crucial during pregnancy. However, the macro- and micronutrient intake also impacts the body's regulatory supersystems of the mother, such as the immune, endocrine, and nervous systems, which ultimately influence the overall development of the offspring. Of particular importance is the association between unhealthy maternal diet and neurodevelopmental disorders in the offspring. Epidemiological studies have linked neurodevelopmental disorders like autism spectrum disorders, attention-deficit-hyperactivity disorder, and schizophrenia, to maternal immune activation (MIA) during gestation. While the deleterious consequences of diet-induced MIA on offspring neurodevelopment are increasingly revealed, neuroinflammation is emerging as a key underlying mechanism. In this review, we compile the evidence available on how the mother and offspring are both impacted by maternal dietary imbalance. We specifically explore the various inflammatory and anti-inflammatory effects of dietary components and discuss how changes in inflammatory status can prime the offspring brain development toward neurodevelopmental disorders. Lastly, we discuss research evidence on the mechanisms that sustain the relationship between maternal dietary imbalance and offspring brain development, involving altered neuroinflammatory status in the offspring, as well as genetic to cellular programming notably of microglia, and the evidence that the gut microbiome may act as a key mediator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.