ArticleNature2021
Bayesian reaction optimization as a tool for chemical synthesis.
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 248 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
248 citing papers in PubMed.
- AI-Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery.Medicinal research reviews · 2026Review
- AIMNet2-rxn: A machine-learned potential for generalized reaction modeling on a millions-of-pathways scale.Science advances · 2026Article
- Structured HTE Data and Integrated Bayesian Optimization Accelerate Scalable Amidation Process Development.ACS organic & inorganic Au · 2026Article
- Bayesian optimization- and high-throughput-guided synthesis of monofluoroalkenesChemical science · 2026Article
- A Practical Guide to Bayesian Optimization for Organic Chemists.Chem catalysis · 2026Article
- DiploPhos: A Hemilabile Bisphosphine for Sterically Hindered Ni-Catalyzed Suzuki-Miyaura Couplings.ACS catalysis · 2026Article
- Active learning sequential surrogate-based optimization (AL-SSBO) versus response surface methodology in sunflower oil diacylglycerol synthesis: Performance and insight into AL-SSBO.Food chemistry: X · 2026Article
- Docking-score landscapes shape active-learning performance across Vina, Glide, and SILCS.Journal of computer-aided molecular design · 2026Article
- Transforming Molecular Synthesis With Large Language Models.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- AI-Based Retrosynthesis of Known and Unexplored Covalent Organic Framework Monomers.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- BayesianKAN: A reaction condition optimization framework integrating Kolmogorov-Arnold network and Bayesian optimization.Smart molecules : open access · 2026Article
- Development and Validation of an Interpretable Machine Learning Model for Predicting Distant Metastasis in Tongue Squamous Cell Carcinoma: A Multicentre Study.International dental journal · 2026Article
- Combining High-Throughput Experimentation and Automated Flow for Bayesian Optimization of a Metallaphotoredox Reaction.Angewandte Chemie (International ed. in English) · 2026Article
- Machine learning-assisted development of a fast Mechanochemical Johnson-Corey-Chaykovsky reaction.Nature communications · 2026Article
- Machine Learning-Empowered Electromagnetic Wave Absorbing Materials: From Forward Prediction to Generative Inverse Design.Molecules (Basel, Switzerland) · 2026Review
- Synthesis and machine learning techniques to enable data-driven investigation of supramolecular host-guest interactions.Chemical science · 2026Article
- A 50,688-Reaction Data Set Reveals General Ligands and Mechanistic Diversity in C-N Couplings.Journal of the American Chemical Society · 2026Article
- Accelerating Reaction Discovery through AI-HTE Integration: Nitrene-Mediated C-O Coupling as a Validated Case Study.JACS Au · 2026Article
- Breaking the Boundaries of Bayesian Optimization Utilizing Continuous Chemistry Digital Twins.Organic process research & development · 2026Article
- Bayesian-enhanced closed-loop optimization of ultrasound protocols for targeted and precise neuromodulation.bioRxiv : the preprint server for biology · 2026Article
188 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reaction optimization is fundamental to synthetic chemistry, from optimizing the yield of industrial processes to selecting conditions for the preparation of medicinal candidates
Indexed as
Identifiers
33536653What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.