ArticleNature2021
BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
- Phosphatase and tensin homolog: A potential target for therapeutic intervention in optic nerve regeneration.Neural regeneration research · 2026Article
- DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.Cell death and differentiation · 2025Article
- Transcription-replication conflict resolution by nuclear RNA interference.Molecular cell · 2025Article
- Breast cancer gene-1 (BRCA1) potentiates maladaptive repair after kidney injury.The Journal of experimental medicine · 2025Article
- RNA transcripts serve as a template for double-strand break repair in human cells.Nature communications · 2025Article
- Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers.Cancer discovery · 2025Review
- Repeat expansion in a fragile X model is independent of double strand break repair mediated by Pol θ, RAD52, RAD54 or RAD54B.Scientific reports · 2025Article
- Multifunctional nanoplatforms based on RNA interference for glioma treatment.American journal of cancer research · 2025Review
- Traffic light at DSB-transit regulation between gene transcription and DNA repair.FEBS letters · 2025Review
- Repeat expansion in a Fragile X model is independent of double strand break repair mediated by Pol θ, Rad52, Rad54l or Rad54b.bioRxiv : the preprint server for biology · 2024Article
- Structural Motifs at the Telomeres and Their Role in Regulatory Pathways.Biochemistry · 2024Review
- Gross Chromosomal Rearrangement at Centromeres.Biomolecules · 2023Review
- R-Loops in Genome Instability and Cancer.Cancers · 2023Review
- C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption.Nature communications · 2023Article
- A transcription-independent mechanism determines rapid periodic fluctuations of BRCA1 expression.The EMBO journal · 2023Article
- Genome stability‑related lncRNA ZFPM2‑AS1 promotes tumor progression via miR‑3065‑5p/XRCC4 in hepatocellular carcinoma.International journal of oncology · 2023Article
- Unscheduled epigenetic modifications cause genome instability and sterility through aberrant R-loops following starvation.Nucleic acids research · 2023Article
- Immunomodulation-a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system.Frontiers in immunology · 2023Review
- RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA.Molecular cell · 2022Article
- Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.Nature reviews. Molecular cell biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Elodie HatchiDepartment of Genetics, Harvard Medical School, Boston, MA, USA. elodie_hatchi@dfci.harvard.edu.ORCID http://orcid.org/0000-0001-8494-9851
Liana Goehring *Department of Genetics, Harvard Medical School, Boston, MA, USA.
Serena Landini *Department of Genetics, Harvard Medical School, Boston, MA, USA.
Konstantina Skourti-Stathaki *Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Derrick K DeContiQuantitative Biomedical Research Center, Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Fieda O AbderazzaqDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Priyankana BanerjeeDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Timothy M DemersDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Yaoyu E WangQuantitative Biomedical Research Center, Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
John QuackenbushQuantitative Biomedical Research Center, Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2702-5879
David M LivingstonDepartment of Genetics, Harvard Medical School, Boston, MA, USA. david_livingston@dfci.harvard.edu.
Harvard University · USQuantitative BioSciences · USWellcome Centre for Cell Biology · GB
Funding
Use of Organotypic and Mammary Gland Models to Investigate the Outcomes of ClonalP01CA080111 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI DILLON, DEBORAH · 1999 to 2018
$36.0MUnraveling the Complexities of Risk and Mechanism in CancerR35CA220523 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI QUACKENBUSH, JOHN · 2018 to 2024
$6.0MBRCA1 Function in Post-Damage Nuclear FociR01CA136512 · NCI · DANA-FARBER CANCER INST · PI LIVINGSTON, DAVID MORSE · 2009 to 2019
$4.6MQuantitative Radiomics System Decoding the Tumor PhenotypeU24CA194354 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.5MGenotype and Imaging Phenotype Biomarkers in Lung CancerU01CA190234 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.3MWebMeV: A Robust Platform for Intuitive Genomic Data AnalysisU24CA231846 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI QUACKENBUSH, JOHN · 2019 to 2023
$3.2MDeciphering the mechanism underlying BRCA1 breast cancer developmentR35CA242143 · NCI · DANA-FARBER CANCER INST · PI LIVINGSTON, DAVID MORSE · 2019 to 2021
$3.0MNCI NIH HHS P01 CA080111NCI NIH HHS R01 CA136512NCI NIH HHS R35 CA220523NCI NIH HHS R35 CA242143NCI NIH HHS U01 CA190234NCI NIH HHS U24 CA194354NCI NIH HHS U24 CA231846Wellcome Trust
Abstract
Strong connections exist between R-loops (three-stranded structures harbouring an RNA:DNA hybrid and a displaced single-strand DNA), genome instability and human disease
Indexed as
DNA RepairRNA InterferenceArgonaute ProteinsBRCA1 ProteinCell Cycle ProteinsDNA DamageEukaryotic Initiation FactorsFanconi Anemia Complementation Group N ProteinHeLa CellsHumansRad52 DNA Repair and Recombination ProteinResting Phase, Cell CycleRibonuclease IIIRNA, Small InterferingAGO1 protein, humanAGO2 protein, humanArgonaute ProteinsBRCA1 ProteinCDT1 protein, humanCell Cycle ProteinsEukaryotic Initiation FactorsFanconi Anemia Complementation Group N ProteinPALB2 protein, humanRad52 DNA Repair and Recombination ProteinRAD52 protein, humanRibonuclease IIIRNA, Small Interfering
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.