ArticleNature2021
A gene-environment-induced epigenetic program initiates tumorigenesis.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 2 pooled it
18.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
191 citing papers in PubMed, 2 syntheses or guidelines pooled it, 304 citations in OpenAlex.
- IBD-related inflammatory memory and colorectal cancer: epigenetic mechanisms and microbiome interventions.Frontiers in immunology · 2026Pooled it
- Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.Signal transduction and targeted therapy · 2023Pooled it
- Cell plasticity in cancer and therapy resistance.Experimental & molecular medicine · 2026Review
- Single-cell epigenomics of colorectal cancer.Experimental & molecular medicine · 2026Review
- Multi-stromal organoid co-culture modelling reveals epithelial-fibroblast heterogeneity in pancreatic cancer and pancreatitis.Nature cell biology · 2026Article
- Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer.Cancer discovery · 2026Article
- Article
- Genomic landscape of ERCC alterations in breast and gynecological cancers: implications for targeted therapy and VUS reclassification.Molecular biology reports · 2026Article
- Evolutionarily Conserved Epigenetic Regulation of Transcriptional Cell States During Vertebrate Pancreatic Tumorigenesis.Cellular and molecular gastroenterology and hepatology · 2026Article
- Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.Developmental cell · 2026Article
- Immune surveillance and immune evasion of senescent cells.Nature reviews. Immunology · 2026Review
- The basal cell state maintains pancreatic cancers by controlling an immunosuppressive circuit.bioRxiv : the preprint server for biology · 2026Article
- Host heterogeneity shapes clonal selection and organotropism in an extranodal lymphoma mouse model.Cell death & disease · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Article
- Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation.Developmental cell · 2026Article
- A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention, and Interception.Cancer discovery · 2026Review
- Recent advances in the pathophysiology of acute and chronic graft-versus-host disease.International journal of hematology · 2026Review
- GATA4 loss promotes mutantbioRxiv : the preprint server for biology · 2026Article
- Article
131 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 3 institutions in 1 country.
Direna Alonso-CurbeloCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yu-Jui HoCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cassandra BurdziakComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jesper L V MaagCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
John P MorrisCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rohit ChandwaniHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hsuan-An ChenCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8979-3670
Kaloyan M TsanovCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Francisco M BarrigaCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0996-7707
Wei LuanCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nilgun TasdemirCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Geulah LivshitsCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Elham AziziComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jaeyoung ChunComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4164-0691
John E WilkinsonDepartment of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Linas MazutisComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Steven D LeachHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2689-1871
Richard KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6820-5083
Dana Pe'erComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Scott W LoweCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lowes@mskcc.org.ORCID http://orcid.org/0000-0002-5284-9650
Memorial Sloan Kettering Cancer Center · USDartmouth College · USUniversity of Michigan · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MVIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MTumor-specific T cell state dynamics and heterogeneity in early tumorigenesisU54CA209975 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LESLIE, CHRISTINA S, RUDENSKY, ALEXANDER Y · 2016 to 2021
$11.8MTranslational Research in Oncology Training ProgramT32CA160001 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SAWYERS, CHARLES L. · 2011 to 2020
$2.0MComprehensive genetic dissection of druggable KRAS targetsR01CA204228 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEACH, STEVEN D · 2016 to 2020
$1.9MIntegrative framework for identifying dysregulated mechanisms in the tumor-immune microenvironmentR00CA230195 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI AZIZI, ELHAM · 2020 to 2022
$652kIntegrative framework for identifying dysregulated mechanisms in the tumor-immune microenvironmentK99CA230195 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI AZIZI, ELHAM · 2018 to 2019
$269kNon-canonical FADD signaling as a genetic driver of invasive lobular carcinomaK99CA237736 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TASDEMIR, NILGUN · 2019 to 2020
$256kMechanisms of tumor suppression by epigenetic regulators in pancreatic cancerF32CA177072 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LIVSHITS, GEULAH YEVGENIYA · 2013 to 2016
$168kSingle Cell Dissection of Epigenetic and Tumor Ecosystem Dynamics During Pancreatic Cancer ProgressionF31CA246901 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BURDZIAK, CASSANDRA · 2020 to 2022
$119kDissecting the mechanisms of immune surveillance and evasion in liver cancerF99CA245797 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHEN, HSUAN-AN · 2019 to 2021
$114kHoward Hughes Medical InstituteNCI NIH HHS F31 CA246901NCI NIH HHS F32 CA177072NCI NIH HHS F99 CA245797NCI NIH HHS K99 CA230195NCI NIH HHS K99 CA237736NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA023108NCI NIH HHS R00 CA230195NCI NIH HHS R01 CA204228NCI NIH HHS T32 CA160001NCI NIH HHS U54 CA209975NIH HHS 5T32CA160001-08
Abstract
Tissue damage increases the risk of cancer through poorly understood mechanisms
Indexed as
Epigenesis, GeneticGene-Environment InteractionAdenocarcinomaAnimalsBromodomain Containing ProteinsCarcinoma, Pancreatic DuctalCell Transformation, NeoplasticChromatinDisease Models, AnimalFemaleGenomicsHumansInterleukin-33MaleMiceMice, Inbred C57BLBrd4 protein, mouseBromodomain Containing ProteinsChromatinInterleukin-33Nuclear ProteinsTranscription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.