Evidence map›Paper›PMID 33536559›Full record

Observational studyScientific reports2021

Differential DNA methylation in recovery from shift work disorder.

Alexandra Lahtinen, Antti Häkkinen, Sampsa Puttonen, Päivi Vanttola, Katriina Viitasalo, Tarja Porkka-Heiskanen, Mikko Härmä, Tiina Paunio

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Recovery from shift work.Frontiers in neurology · 2023
    Review
  10. Circadian Mechanisms in Medicine.The New England journal of medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Alexandra LahtinenDepartment of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Biomedicum 1, Haartmaninkatu 8, 00290, Helsinki, Finland. alexandra.lahtinen@helsinki.fi.
Antti HäkkinenResearch Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sampsa PuttonenWork Ability and Working Careersareers, Finnish Institute of Occupational Health, PO Box 40, 00032, Helsinki, Finland.
Päivi VanttolaWork Ability and Working Careersareers, Finnish Institute of Occupational Health, PO Box 40, 00032, Helsinki, Finland.
Katriina ViitasaloFinnair Health Services, HEL-IF/67, 01053, Finnair, Finland.
Tarja Porkka-HeiskanenDepartment of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Biomedicum 1, Haartmaninkatu 8, 00290, Helsinki, Finland.
Mikko HärmäWork Ability and Working Careersareers, Finnish Institute of Occupational Health, PO Box 40, 00032, Helsinki, Finland.
Tiina PaunioDepartment of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Biomedicum 1, Haartmaninkatu 8, 00290, Helsinki, Finland. tiina.paunio@helsinki.fi.
Finnish Institute of Occupational Health · FIUniversity of Helsinki · FIFinnair (Finland) · FIFinnish Institute for Health and Welfare · FIHelsinki University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human DNA methylome is responsive to our environment, but its dynamics remain underexplored. We investigated the temporal changes to DNA methylation (DNAme) in relation to recovery from a shift work disorder (SWD) by performing a paired epigenome-wide analysis in an occupational cohort of 32 shift workers (25 men, age = 43.8 ± 8.8 years, 21 SWD cases). We found that the effect of vacation on DNAme was more prominent in the SWD-group as compared to controls, with respect to the amount of significantly differentially methylated positions (DMPs; P

Indexed as

DNA MethylationEpigenesis, GeneticAdultCalcium-Calmodulin-Dependent Protein Kinase Type 2Case-Control StudiesCyclic AMP Response Element-Binding ProteinFemaleGenome-Wide Association StudyHumansMaleMiddle AgedReceptors, N-Methyl-D-AspartateShift Work ScheduleSleep Disorders, Circadian RhythmCalcium-Calmodulin-Dependent Protein Kinase Type 2CAMK2B protein, humanCREB1 protein, humanCyclic AMP Response Element-Binding ProteinGRIN2C protein, humanReceptors, N-Methyl-D-Aspartate

Identifiers

PMID33536559
PMCPMC7858604
OpenAlexW3128402193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.