Observational studyScientific reports2021
Direct and rapid measurement of hydrogen peroxide in human blood using a microfluidic device.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Hydrogen peroxide sensing and signaling in physiology and disease: implications for therapy.Signal transduction and targeted therapy · 2026Review
- Cell-derived lactate triggers local hydrogelation and phenotype remodelling.Nature communications · 2026Article
- Selective lysosomal HRSC advances · 2026Article
- A new insight of a pH-dependent fluorescence switching mechanism and the novel radical scavenging ability of nitrogen-doped citric acid-based carbon dots.RSC advances · 2026Article
- Sustained low micromolar hydrogen peroxide exposure induces sequential red blood cell dysfunction.Frontiers in physiology · 2026Article
- Various Configurations of Au@Pt Nanostructures on Modified Electrochemical Sensors for HACS applied nano materials · 2025Article
- Self-Maintainable Electronic Materials with Skin-Like Characteristics Enabled by Graphene-PEDOT:PSS Fillers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microfluidics and nanofluidics in India - some recent advancements and futuristic perspective.Biomicrofluidics · 2025Article
- EngineeredACS synthetic biology · 2025Article
- Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)-Sensitive Triggers.Angewandte Chemie (International ed. in English) · 2024Review
- Cellular Pre-Adaptation to the High OAntioxidants (Basel, Switzerland) · 2024Article
- Assessment of hydrogen peroxide as a bioindicator of stress in seaweed aquaculture.Scientific reports · 2024Article
- Unravelling the Mechanistic Understanding of Metal Nanoparticle-Induced Reactive Oxygen Species Formation: Insights from a Cu Nanoparticle Study.Chemical research in toxicology · 2023Article
- Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane.International journal of molecular sciences · 2023Article
- Hybridization of CoBiosensors · 2023Article
- Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide.World journal of gastroenterology · 2022Review
- Encapsulation Capacity of β-Cyclodextrin Stabilized Silver Nanoparticles towards Creatinine Enhances the Colorimetric Sensing of Hydrogen Peroxide in Urine.Nanomaterials (Basel, Switzerland) · 2021Article
- A novel MnO-CrN nanocomposite based non-enzymatic hydrogen peroxide sensor.RSC advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The levels of hydrogen peroxide ([Formula: see text]) in human blood is of great relevance as it has emerged as an important signalling molecule in a variety of disease states. Fast and reliable measurement of [Formula: see text] levels in the blood, however, continues to remain a challenge. Herein we report an automated method employing a microfluidic device for direct and rapid measurement of [Formula: see text] in human blood based on laser-induced fluorescence measurement. Our study delineates the critical factors that affect measurement accuracy-we found blood cells and soluble proteins significantly alter the native [Formula: see text] levels in the time interval between sample withdrawal and detection. We show that separation of blood cells and subsequent dilution of the plasma with a buffer at a ratio of 1:6 inhibits the above effect, leading to reliable measurements. We demonstrate rapid measurement of [Formula: see text] in plasma in the concentration range of 0-49 µM, offering a limit of detection of 0.05 µM, a sensitivity of 0.60 µM
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.