Evidence map›Paper›PMID 33536517›Full record

ArticleScientific reports2021

Exceptional antibacterial and cytotoxic potency of monodisperse greener AgNPs prepared under optimized pH and temperature.

Muhammad Riaz, Vishal Mutreja, Shweta Sareen, Bashir Ahmad, Muhammad Faheem, Nafeesa Zahid, Ghassan Jabbour, Jeongwon Park

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Green synthesis ofFrontiers in pharmacology · 2025
    Article
  11. Article
  12. Article
  13. Medicine and pharmacy reports · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhammad RiazSchool of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Vishal MutrejaSchool of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Shweta SareenDepartment of Chemistry, Panjab University, Sector-14, Chandigarh, India.
Bashir AhmadDepartment of Biological Sciences, International Islamic University Islamabad, Islamabad, 44000, Pakistan.
Muhammad FaheemDepartment of Biological Sciences, International Islamic University Islamabad, Islamabad, 44000, Pakistan.
Nafeesa ZahidDepartment of Botany, Mirpur University of Science and Technology (MUST), Mirpur, 10250, Azad Kashmir, Pakistan.
Ghassan JabbourSchool of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Jeongwon ParkSchool of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, K1N 6N5, Canada. jepark@unr.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present work, silver nanoparticles were prepared by using the extract of Camellia Sinensis. The extract contains phytochemicals which are mainly polyphenols acting as the natural reducing and stabilizing agents leading to the formation of uniformly dispersed and stabilized silver nanoparticles. The synthesis of silver nanoparticles was significantly influenced by the impact of the pH, as well as temperature conditions. It was found that at pH 5 and 25 °C, nanoparticles of different morphologies (spherical, polygonal, capsule) and sizes were formed. However, with the increase in temperature from 25 °C to 65 °C but at the same pH, these particles started attaining the spherical shape of different sizes owing to an increase in the reduction rate. Furthermore, for the reaction of the mixture at 65 °C, an increase in pH from 5 to 11 led to an increase in the monodispersity of spherically shaped nanoparticles, attributed to the hydroxide ions facilitated reduction. The prepared nanoparticles were investigated for their antibacterial activity using Nathan's Agar Well-Diffusion method. It was found that AgNPs prepared at pH 9 and 65 °C demonstrated strong antibacterial activity against gram-negative Escherichia coli in contrast to gram-positive Staphylococcus aureus. In reference to the cytotoxic potency, the prepared AgNPs showed clear cytotoxicity for HeLa cells and showcased a close relationship between activity and concentration as evidenced by the decrease in the percentage (100 to 30%) of metabolically active cells up to 25 µM-75 µM concentration of silver nanoparticles.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCamellia sinensisDrug Screening Assays, AntitumorEscherichia coliHeLa CellsHumansHydrogen-Ion ConcentrationMetal NanoparticlesMicrobial Sensitivity TestsPlant ExtractsSilverStaphylococcus aureusTemperatureAnti-Bacterial AgentsAntineoplastic AgentsPlant ExtractsSilver

Identifiers

PMID33536517
PMCPMC7858571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.