Observational studyScientific reports2021
Low muscle strength and increased arterial stiffness go hand in hand.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Muscle Strength as a Key Independent Predictor of Arterial Stiffness and Metabolic Syndrome in Aging Mexicans: Unveiling the Sarcopenic Obesity Paradox.Journal of clinical medicine · 2026Article
- Associations of Handgrip Strength Weakness and Asymmetry With New-Onset Stroke in Middle-Aged and Older Adults: A Prospective Cohort Study in Europe.Geriatrics & gerontology international · 2026Article
- Age moderates the association between handgrip strength and large artery stiffness in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Association between handgrip strength to Cystatin C ratio and hearing loss: insights from the CHARLS study.Journal of health, population, and nutrition · 2025Article
- Association between health-related physical fitness and incident hypertension among the elderly in Wuhan: a seven-year cohort study.BMC public health · 2025Article
- Associations of Physical Fitness During Childhood with Arterial Structure and Stiffness in Adolescence: An 8-Year Follow-up Study.Sports medicine - open · 2025Article
- Use of Handgrip Strength as a Health Indicator in Public Sector Workers: A Cross-Sectional Study.Journal of functional morphology and kinesiology · 2025Article
- Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study.The journal of nutrition, health & aging · 2024Article
- Factors Affecting Arterial Stiffness and Brachial-Ankle Pulse Wave Velocity in Patients With Type 2 Diabetes.Cureus · 2024Article
- Relationship between Pulse Pressure and Handgrip Strength in the Korean Population: A Nationwide Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Hand grip strength as a proposed new vital sign of health: a narrative review of evidences.Journal of health, population, and nutrition · 2024Review
- Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults.Frontiers in nutrition · 2024Article
- Handgrip Strength Is Associated with Specific Aspects of Vascular Function in Individuals with Metabolic Syndrome.Biomedicines · 2023Article
- Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults.Journal of clinical medicine · 2023Article
- Association Between Pulse Wave Velocity and Frailty, Disability, and Mortality in Community-Dwelling Older Adults.JACC. Advances · 2023Article
- Arterial stiffness expressed as brachial-ankle pulse wave velocity and gait assessment independent of lower extremity strength: a cross-sectional study in the older men population.Journal of geriatric cardiology : JGC · 2023Article
- Sex-specific associations between cardiovascular risk factors and physical function: the Gambian Bone and Muscle Ageing Study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Associations of cardiorespiratory fitness, body composition, and blood pressure with arterial stiffness in adolescent, young adult, and middle-aged women.Scientific reports · 2022Article
- Article
- SARC-F Is a Predictor of Longer LOS and Hospital Readmission in Hospitalized Patients after a Cardiovascular Event.Nutrients · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low handgrip strength and increased arterial stiffness are both associated with poor health outcomes, but evidence on the relationship between handgrip strength and arterial stiffness is limited. In this cross-sectional analysis of combined baseline datasets from the LipidCardio and Berlin Aging Study II cohorts we aimed to examine whether handgrip strength (HGS) is associated with arterial stiffness. 1511 participants with a median age of 68.56 (IQR 63.13-73.08) years were included. Arterial stiffness was assessed by aortal pulse wave velocity (PWV) with the Mobil-O-Graph device. Handgrip strength was assessed with a handheld dynamometer.The mean HGS was 39.05 ± 9.07 kg in men and 26.20 ± 7.47 kg in women. According to multivariable linear regression analysis per 5 kg decrease in handgrip strength there was a mean increase in PWV of 0.08 m/s after adjustment for the confounders age, sex, coronary artery disease, systolic blood pressure, body mass index, cohort, and smoking. Thus, there was evidence that low handgrip strength and increased arterial stiffness go hand in hand. Arterial stiffness can possibly create the missing link between low handgrip strength and increased cardiovascular morbidity and mortality. Causality and direction of causality remain to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.