ArticleTranslational psychiatry2021
Thalamocortical connectivity is associated with autism symptoms in high-functioning adults with autism and typically developing adults.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Championing neurodiversity and human potential: an interview with Lawrence Fung.Communications biology · 2026Article
- Subcortical dopamine DEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Hyperactivation of distinct thalamic nuclei differentially impairs sleep physiology in rats.Molecular psychiatry · 2026Article
- Autism Spectrum Disorder-Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions.The European journal of neuroscience · 2026Article
- Spatial transcriptomics implicates the thalamus and cortex in autism and schizophrenia.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporal analysis of autism gene enrichment implicates cortex, thalamus, and hypothalamus.bioRxiv : the preprint server for biology · 2026Article
- Aperiodic and periodic neural activity during sleep in autism spectrum disorders.BMC medicine · 2026Article
- Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.Neurobiology of learning and memory · 2026Article
- Lean-NET-Based Local Brain Connectome Analysis for Autism Spectrum Disorder Classification.Bioengineering (Basel, Switzerland) · 2026Article
- Alterations in self-related brain networks in autism spectrum disorder: a systematic review of functional and structural magnetic resonance imaging studies.Psychoradiology · 2026Review
- Linking auditory brain responses to cortical microstructure and sensory behaviors in autism spectrum disorder: a preliminary study.Frontiers in psychiatry · 2026Article
- Thalamus-cortex interactions drive cell type-specific cortical development in human pluripotent stem cell-derived assembloids.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dissecting the heterogeneity of autism spectrum disorder with sensory behavior, brain, and epigenetic factors.Translational psychiatry · 2025Article
- Reticular thalamic hyperexcitability drives autism spectrum disorder behaviors in the Cntnap2 model of autism.Science advances · 2025Article
- Disrupted diencephalon development and neuropeptidergic pathways in zebrafish with autism-risk mutations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Atypical maturation of the functional connectome hierarchy in autism.Molecular autism · 2025Article
- Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey.Psychopharmacology · 2025Article
- Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons.Nature communications · 2025Article
- Sex Differences in the Relationship Between Cortical Thickness and Sensory Motor Symptoms in Adults on the Autism Spectrum.Behavioural neurology · 2025Article
- The cost of language: functionally over-dominant language circuits in the human brain may limit cognitive abilities and non-verbal executive functions.Frontiers in human neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Alterations in sensorimotor functions are common in individuals with autism spectrum disorder (ASD). Such aberrations suggest the involvement of the thalamus due to its key role in modulating sensorimotor signaling in the cortex. Although previous research has linked atypical thalamocortical connectivity with ASD, investigations of this association in high-functioning adults with autism spectrum disorder (HFASD) are lacking. Here, for the first time, we investigated the resting-state functional connectivity of the thalamus, medial prefrontal, posterior cingulate, and left dorsolateral prefrontal cortices and its association with symptom severity in two matched cohorts of HFASD. The principal cohort consisted of 23 HFASD (mean[SD] 27.1[8.9] years, 39.1% female) and 20 age- and sex-matched typically developing controls (25.1[7.2] years, 30.0% female). The secondary cohort was a subset of the ABIDE database consisting of 58 HFASD (25.4[7.8] years, 37.9% female) and 51 typically developing controls (24.4[6.7] years, 39.2% female). Using seed-based connectivity analysis, between-group differences were revealed as hyperconnectivity in HFASD in the principal cohort between the right thalamus and bilateral precentral/postcentral gyri and between the right thalamus and the right superior parietal lobule. The former was associated with autism-spectrum quotient in a sex-specific manner, and was further validated in the secondary ABIDE cohort. Altogether, we present converging evidence for thalamocortical hyperconnectivity in HFASD that is associated with symptom severity. Our results fill an important knowledge gap regarding atypical thalamocortical connectivity in HFASD, previously only reported in younger cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.