ArticleNature communications2021
A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Diverse anelloviruses identified in wild geladas (Theropithecus gelada).Archives of virology · 2026Article
- In vitro growth and characterization of 'Candidatus Sarcina troglodytae' isolated from the brain of a chimpanzee in Sierra Leone.Access microbiology · 2026Article
- Distribution and prevalence ofJournal of medical microbiology · 2025Article
- Intestinal microbiota profiles of captive-bred cynomolgus macaques reveal influence of biogeography and age.Animal microbiome · 2025Article
- Etiology and risk factors of hemorrhagic abomasitis in goat kids.Scientific reports · 2025Article
- The Interface Between Veterinary and Behavioral Management of Chimpanzees (Veterinary sciences · 2024Article
- CRISPR-Cas9-mediated host signal reduction for 18S metabarcoding of host-associated eukaryotes.Molecular ecology resources · 2024Article
- Bacterial community of ticks (Acari: Ixodidae) and mammals from Arauca, Colombian Orinoquia.International journal for parasitology. Parasites and wildlife · 2024Article
- Gastrointestinal tract pathology of the owl monkey (Veterinary pathology · 2024Article
- Maternal Malic Acid May Ameliorate Oxidative Stress and Inflammation in Sows through Modulating Gut Microbiota and Host Metabolic Profiles during Late Pregnancy.Antioxidants (Basel, Switzerland) · 2024Article
- High frequencies of nonviral colds and respiratory bacteria colonization among children in rural Western Uganda.Frontiers in pediatrics · 2024Article
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Article
- Species and Strain Variability amongAnimals : an open access journal from MDPI · 2023Article
- Viruses in sanctuary chimpanzees across Africa.American journal of primatology · 2023Article
- Viruses in saliva from sanctuary chimpanzees (Pan troglodytes) in Republic of Congo and Uganda.PloS one · 2023Article
- Non-operative Management of Sarcina ventriculi-Associated Severe Emphysematous Gastritis: A Case Report.Cureus · 2022Article
- Variation in the intestinal microbiota at different developmental stages ofEcology and evolution · 2022Article
- A Faithful Gut: Core Features of Gastrointestinal Microbiota of Long-Distance Migratory Bats Remain Stable despite Dietary Shifts Driving Differences in Specific Bacterial Taxa.Microbiology spectrum · 2021Article
- Generalized tympanism in a horse and its possible association withOpen veterinary journalArticle
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 8 institutions in 5 countries.
Funding
Abstract
Human and animal infections with bacteria of the genus Sarcina (family Clostridiaceae) are associated with gastric dilation and emphysematous gastritis. However, the potential roles of sarcinae as commensals or pathogens remain unclear. Here, we investigate a lethal disease of unknown etiology that affects sanctuary chimpanzees (Pan troglodytes verus) in Sierra Leone. The disease, which we have named "epizootic neurologic and gastroenteric syndrome" (ENGS), is characterized by neurologic and gastrointestinal signs and results in death of the animals, even after medical treatment. Using a case-control study design, we show that ENGS is strongly associated with Sarcina infection. The microorganism is distinct from Sarcina ventriculi and other known members of its genus, based on bacterial morphology and growth characteristics. Whole-genome sequencing confirms this distinction and reveals the presence of genetic features that may account for the unusual virulence of the bacterium. Therefore, we propose that this organism be considered the representative of a new species, named "Candidatus Sarcina troglodytae". Our results suggest that a heretofore unrecognized complex of related sarcinae likely exists, some of which may be highly virulent. However, the potential role of "Ca. S. troglodytae" in the etiology of ENGS, alone or in combination with other factors, remains a topic for future research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.