ArticleNature communications2021
Cryptochrome 1 mediates light-dependent inclination magnetosensing in monarch butterflies.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Pooled it
- Genetic analysis of cryptochrome in insect magnetosensitivity.Frontiers in physiology · 2022Pooled it
- Not all butterflies are monarchs: orientation using daytime celestial cues but not magnetic cues in European migratory red admirals (Vanessa atalanta).Journal of the Royal Society, Interface · 2026Article
- Echolocating free-tailed bats use vision and hearing but not magnetoreception when navigating a maze.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Article
- From skylight cues to magnetic fields: the toolkit of insect long-distance navigation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Emerging tools to advance neuroethology in butterflies and moths.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- The diversity of lepidopteran spatial orientation strategies - neuronal mechanisms and emerging challenges in a changing world.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- A north-south hemispheric migratory divide in the butterfly Vanessa cardui.Nature communications · 2025Article
- Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception.iScience · 2025Article
- Cryptochrome 4b protein is probably irrelevant for radical pair-based magnetoreception in the European robin.Journal of the Royal Society, Interface · 2025Article
- Neuromorphic encoding strategies for a noisy magnetic sense.Journal of the Royal Society, Interface · 2025Article
- Spatiotemporal computations in the insect celestial compass.Nature communications · 2025Article
- Article
- Monarch butterflies (Danaus plexippus) only use magnetic cues for migratory directionality with orientation re-calibrated by coldness.PloS one · 2025Article
- Cryptochrome magnetoreception: Time course of photoactivation from non-equilibrium coarse-grained molecular dynamics.Computational and structural biotechnology journal · 2024Article
- Comparison of retinol binding protein 1 with cone specific G-protein as putative effector molecules in cryptochrome signalling.Scientific reports · 2024Article
- CRY1 is involved in the take-off behaviour of migratory Cnaphalocrocis medinalis individuals.BMC biology · 2024Article
- Functional Analyses of Four Cryptochromes From Aquatic Organisms After Heterologous Expression inJournal of biological rhythms · 2024Article
- Magnetic field effects on behaviour in Drosophila.Nature · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many animals use the Earth's geomagnetic field for orientation and navigation. Yet, the molecular and cellular underpinnings of the magnetic sense remain largely unknown. A biophysical model proposed that magnetoreception can be achieved through quantum effects of magnetically-sensitive radical pairs formed by the photoexcitation of cryptochrome (CRY) proteins. Studies in Drosophila are the only ones to date to have provided compelling evidence for the ultraviolet (UV)-A/blue light-sensitive type 1 CRY (CRY1) involvement in animal magnetoreception, and surprisingly extended this discovery to the light-insensitive mammalian-like type 2 CRYs (CRY2s) of both monarchs and humans. Here, we show that monarchs respond to a reversal of the inclination of the Earth's magnetic field in an UV-A/blue light and CRY1, but not CRY2, dependent manner. We further demonstrate that both antennae and eyes, which express CRY1, are magnetosensory organs. Our work argues that only light-sensitive CRYs function in animal light-dependent inclination-based magnetic sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.