ArticleNature communications2021
Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 84 citations in OpenAlex.
- Noninvasive Focal Gene Delivery of Functional Neural Actuators to the Primate Spinal Cord using Focused Ultrasound.bioRxiv : the preprint server for biology · 2026Article
- Integrating efficient and tailored perovskite and organic solar cells into performance-improved tandem photovoltaics.Chemical science · 2026Review
- Simulated closed-loop magnetic stimulation promotes function recovery and axonal regeneration in spinal cord injury.Communications biology · 2026Article
- Edge AI-Based Gait-Phase Detection for Closed-Loop Neuromodulation in SCI Mice.Sensors (Basel, Switzerland) · 2026Article
- Widefield Targeted Illumination Microscopy Enables Optically-Sectioned, Motion-Resilient Imaging of Neuronal Fibers and Their Dynamics.Laser & photonics reviews · 2025Article
- Functional recovery induced by KCC2-enabled relay pathways in completely injured spinal cords in adult rats.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord.Nature communications · 2025Article
- Biomaterial-Based Emergency Intervention for Secondary Spinal Cord Injury.Small science · 2025Review
- Sensory Deficits in Mice with Lateral Spinal Cord Hemisection Mimic the Brown-Séquard Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury.Communications biology · 2025Article
- Spinal cord ischemia reperfusion injury induces cuproptosis in neurons.Cell & bioscience · 2025Article
- Anatomical and behavioral characterization of three hemiplegic animal models.BMC neuroscience · 2025Article
- Traumatic spinal cord injury: a review of the current state of art and future directions - what do we know and where are we going?North American Spine Society journal · 2025Article
- Article
- Single-Cell Multi-omics Assessment of Spinal Cord Injury Blocking via Cerium-doped Upconversion Antioxidant Nanoenzymes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multichannel 3D-Printed Bioactive Scaffold Combined with Small Interfering RNA Delivery to Promote Neurological Recovery after Spinal Cord Injury.Research (Washington, D.C.) · 2025Article
- The Circadian Clock Gene Bmal1 Regulates Microglial Pyroptosis After Spinal Cord Injury via NF-κB/MMP9.CNS neuroscience & therapeutics · 2024Article
- M2 Microglia-derived Exosomes Promote Spinal Cord Injury Recovery in Mice by Alleviating A1 Astrocyte Activation.Molecular neurobiology · 2024Article
- Forelimb motor recovery by modulating extrinsic and intrinsic signaling as well as neuronal activity after the cervical spinal cord injury.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
After complete spinal cord injuries (SCI), spinal segments below the lesion maintain inter-segmental communication via the intraspinal propriospinal network. However, it is unknown whether selective manipulation of these circuits can restore locomotor function in the absence of brain-derived inputs. By taking advantage of the compromised blood-spinal cord barrier following SCI, we optimized a set of procedures in which AAV9 vectors administered via the tail vein efficiently transduce neurons in lesion-adjacent spinal segments after a thoracic crush injury in adult mice. With this method, we used chemogenetic actuators to alter the excitability of propriospinal neurons in the thoracic cord of the adult mice with a complete thoracic crush injury. We showed that activating these thoracic neurons enables consistent and significant hindlimb stepping improvement, whereas direct manipulations of the neurons in the lumbar spinal cord led to muscle spasms without meaningful locomotion. Strikingly, manipulating either excitatory or inhibitory propriospinal neurons in the thoracic levels leads to distinct behavioural outcomes, with preferential effects on standing or stepping, two key elements of the locomotor function. These results demonstrate a strategy of engaging thoracic propriospinal neurons to improve hindlimb function and provide insights into optimizing neuromodulation-based strategies for treating SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.