Evidence map›Paper›PMID 33536412›Full record

ArticleNature communications2021

Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact.

Sarah B Nyenhuis, Nakul Karandikar, Volker Kiessling, Alex J B Kreutzberger, Anusa Thapa, Binyong Liang, Lukas K Tamm, David S Cafiso

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. CaScience advances · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dynamic Formation of the Protein-Lipid Pre-fusion Complex.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Article
  9. Long COVID as a Tauopathy: Of "Brain Fog" and "Fusogen Storms".International journal of molecular sciences · 2023
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Virus-Induced Membrane Fusion in Neurodegenerative Disorders.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah B NyenhuisDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Nakul KarandikarDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0001-9574-8131
Volker KiesslingDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-9388-5703
Alex J B KreutzbergerDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-9774-115X
Anusa ThapaDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA.
Binyong LiangDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Lukas K TammDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-1674-4464
David S CafisoDepartment of Chemistry, University of Virginia, Charlottesville, VA, USA. cafiso@virginia.edu.ORCID 0000-0002-3813-8721

Funding

Structural Dynamics of the Exocytotic Fusion Machine in Neurons.P01GM072694 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KIESSLING, VOLKER · 2005 to 2021
$17.4M
NIGMS NIH HHS P01 GM072694
6 · The paper itself

Abstract

Synaptotagmin 1 is a vesicle-anchored membrane protein that functions as the Ca

Indexed as

Membrane FusionAnimalsArginineBinding SitesCalciumCell MembraneNeurotransmitter AgentsProtein BindingProtein DomainsRatsSNARE ProteinsSynaptotagmin IArginineCalciumNeurotransmitter AgentsSNARE ProteinsSynaptotagmin I

Identifiers

PMID33536412
PMCPMC7859215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.