Evidence map›Paper›PMID 33536397›Full record

ArticleJournal of atherosclerosis and thrombosis2022

5-HT

Yingying Ma, Xiurui Liang, Chen Li, Ruoming Li, Xin Tong, Rui Zhang, Xuechun Shan, Jing Yang, Xiaonan Ma, Wenjia Lu and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. [Mechanism ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Multiple Roles of Palmitic Acid in Cardiovascular Diseases.Journal of inflammation research · 2025
    Review
  14. Membrane Transporter of Serotonin and Hypercholesterolemia in Children.International journal of molecular sciences · 2024
    Article
  15. Review
  16. Article
  17. Cardiovascular disease and depression: a narrative review.Frontiers in cardiovascular medicine · 2023
    Review
  18. Article
  19. Review
  20. Serotonin and Atheroscelotic Cardiovascular Disease.Journal of atherosclerosis and thrombosis · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yingying MaLaboratory of Cardiovascular Pharmacology, China Pharmaceutical University.
Xiurui LiangLaboratory of Cardiovascular Pharmacology, China Pharmaceutical University.
Chen LiLaboratory of Cardiovascular Pharmacology, China Pharmaceutical University.
Ruoming LiCollege of basic medicine and clinical pharmacy, China Pharmaceutical University.
Xin TongLaboratory of Cardiovascular Pharmacology, China Pharmaceutical University.
Rui ZhangLaboratory of Cardiovascular Pharmacology, China Pharmaceutical University.
Xuechun ShanLaboratory of Cardiovascular Pharmacology, China Pharmaceutical University.
Jing YangLaboratory of Cardiovascular Pharmacology, China Pharmaceutical University.
Xiaonan MaCellular and Molecular Biology Center of China Pharmaceutical University.
Wenjia LuCollege of basic medicine and clinical pharmacy, China Pharmaceutical University.
Ruitong LiCollege of basic medicine and clinical pharmacy, China Pharmaceutical University.
Jihua FuDepartment of Physiology, China Pharmaceutical University.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPreviously, we found that diabetes-related liver dysfunction is due to activation of the 5-HT

methodsThe study was conducted using high-fat diet-fed male ApoE

resultsIn addition to improving hepatic steatosis, insulin resistance, and dyslipidemia, co-treatment with a 5-HT synthesis inhibitor and a 5-HT

conclusionSimilar to hepatic steatosis, the pathogenesis of lipid-induced atherosclerosis is associated with activation of intracellular 5-HT

Indexed as

AnimalsAtherosclerosisCells, CulturedDisease Models, AnimalEndothelial CellsFoam CellsMacrophagesMaleMiceMice, Inbred C57BLPlaque, AtheroscleroticReceptor, Serotonin, 5-HT2ASerotoninReceptor, Serotonin, 5-HT2ASerotonin5-HT2A receptor5-HT degradation5-HT synthesisMonoamine oxidase A (MAO-A)Reactive oxygen species (ROS)

Identifiers

PMID33536397
PMCPMC8894120
OpenAlexW3127304365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.