ArticleAnnals of laboratory medicine2021
Recent Trends in Creatinine Assays in Korea: Long-Term Accuracy-Based Proficiency Testing Survey Data by the Korean Association of External Quality Assessment Service (2011-2019).
Article in Annals of laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Strengthening the interpretation of longitudinal EQA data through the sporadic inclusion of native human sera in general clinical chemistry.Frontiers in molecular biosciences · 2026Article
- Article
- Association between estimated glomerular filtration rate and memory function mediated by brain Gray matter volumes: a cross-sectional study using the ADNI database.BMC geriatrics · 2025Article
- Current Status of Standardization of Glomerular Filtration Rate Markers in Korea.Annals of laboratory medicine · 2025Article
- Toward High-Quality Real-World Laboratory Data in the Era of Healthcare Big Data.Annals of laboratory medicine · 2025Review
- Laboratory Preparation for Digital Medicine in Healthcare 4.0: An Investigation Into the Awareness and Applications of Big Data and Artificial Intelligence.Annals of laboratory medicine · 2024Article
- Experiences and challenges for EQA providers in assessing the commutability of control materials in accuracy-based EQA programs.Frontiers in medicine · 2024Article
- Laboratory Data Quality Evaluation in the Big Data Era.Annals of laboratory medicine · 2023Article
- Accuracy of the New Creatinine-based Equations for Estimating Glomerular Filtration Rate in Koreans.Annals of laboratory medicine · 2023Article
- Proposed Model for Evaluating Real-world Laboratory Results for Big Data Research.Annals of laboratory medicine · 2023Article
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8 authors.
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Abstract
backgroundAccurate serum creatinine (Cr) concentration measurement is essential for evaluating kidney function. In 2011, the Korean Association of External Quality Assessment Service (KEQAS) launched an accuracy-based Cr proficiency testing (ABCr PT) survey. We analyzed long-term data of the KEQAS ABCr PT survey collected between 2011 and 2019 to assess recent trends in Cr assays in Korea.
methodsThe ABCr PT survey including three commutable fresh-frozen serum samples was performed twice a year. The target Cr concentration was assigned using isotope-dilution mass spectrometry. We analyzed data obtained from the participating laboratories, calculated the yearly bias, and evaluated bias trends for the major reagents and instruments. Outliers were excluded from all analysis.
resultsThe mean percentage bias based on the total data of all participating laboratories was 10.8% in the 2011-A survey and 0.2% in 2019-B survey. Bias for the major reagents and instruments differed depending on the manufacturer. Enzymatic assays generally showed desirable bias ranging from -3.9% to 3.2% at all Cr concentrations and lower interlaboratory variability than non-enzymatic assays (enzymatic vs. non-enzymatic, 3.3%-7.2% vs. 6.3%-9.1%).
conclusionsAlthough the mean percentage bias of Cr assays tends to decrease over time, it is necessary to continuously strive to improve Cr assay accuracy, especially at low concentrations.
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