ArticleProceedings of the National Academy of Sciences of the United States of America2021
Evolutionary dynamics at the tumor edge reveal metabolic imaging biomarkers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Decoding Treatment Response and Prognosis in Unresectable Locally Advanced Non-Small Cell Lung Cancer by Integrating Spatiotemporal Heterogeneity FromJCO precision oncology · 2026Article
- Integrated tumor habitat and metabolic hot spot displacement analysis on [¹⁸F]FDG PET/CT for predicting treatment response and progression in unresectable locally advanced NSCLC: a two-center competing risk study.European journal of nuclear medicine and molecular imaging · 2026Article
- Reproducibility and Potential Prognostic Value of Spatial Metabolic PET Metrics in Oral Tongue Squamous Cell Carcinoma.Cancers · 2026Article
- Complementary prognostic value of hotspot-to-centroid distance (NHOCpeak) to SUVpeak in high-grade glioma.Annals of nuclear medicine · 2026Article
- An explainable imaging-clinical biomarker for non-small cell lung cancer prognostication based on normalised hotspot to centroid distance and [European journal of nuclear medicine and molecular imaging · 2026Article
- A radio-genomics biomarker for precision epidermal growth factor receptor mutation targeting therapy in non-small cell lung cancer.Scientific reports · 2026Article
- NHOC/NHOP as novel biomarkers for predicting lymph node metastasis in NSCLC using PET/CT radiomics and machine learning: a two-center retrospective study.European journal of nuclear medicine and molecular imaging · 2026Article
- Frizzled-9 Expression Is Associated With Aggressive Clinicopathological Features and Reduced Overall Survival in Invasive Breast Carcinoma.Pathology international · 2026Article
- Spatial imaging features derived from SUVmax location in resectable NSCLC are associated with tumor aggressiveness.European journal of nuclear medicine and molecular imaging · 2026Article
- Novel PET imaging biomarkers as predictors of postoperative recurrence in lung adenocarcinoma.BMC cancer · 2025Article
- Clinicopathologic and metabolic variables fromAnnals of nuclear medicine · 2025Article
- Delta Radiomics and Tumor Size: A New Predictive Radiomics Model for Chemotherapy Response in Liver Metastases from Breast and Colorectal Cancer.Tomography (Ann Arbor, Mich.) · 2025Article
- Clinical value of SUVpeak-to-tumor centroid distance on FDG PET/CT for predicting neoadjuvant chemotherapy response in patients with breast cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Spatial interactions modulate tumor growth and immune infiltration.NPJ systems biology and applications · 2024Article
- Spatial interactions modulate tumor growth and immune infiltration.Research square · 2024Article
- Integrated modeling of labile and glycated hemoglobin with glucose for enhanced diabetes detection and short-term monitoring.iScience · 2024Article
- Promising Candidate Prognostic Biomarkers in [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Spatial interactions modulate tumor growth and immune infiltration.bioRxiv : the preprint server for biology · 2024Article
- Deciphering tumor ecosystems at super resolution from spatial transcriptomics with TESLA.Cell systems · 2023Article
- Agent-based methods facilitate integrative science in cancer.Trends in cell biology · 2023Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human cancers are biologically and morphologically heterogeneous. A variety of clonal populations emerge within these neoplasms and their interaction leads to complex spatiotemporal dynamics during tumor growth. We studied the reshaping of metabolic activity in human cancers by means of continuous and discrete mathematical models and matched the results to positron emission tomography (PET) imaging data. Our models revealed that the location of increasingly active proliferative cellular spots progressively drifted from the center of the tumor to the periphery, as a result of the competition between gradually more aggressive phenotypes. This computational finding led to the development of a metric, normalized distance from
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.