Evidence map›Paper›PMID 33536326›Full record

ArticlemSphere2021

The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale.

Che J Ngwa, Mackensie R Gross, Jean-Pierre Musabyimana, Gabriele Pradel, Kirk W Deitsch

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. ThemSphere · 2024
    Article
  2. ThemSphere · 2024
    Article
  3. Review
  4. Review
  5. Host-parasite interactions duringFrontiers in immunology · 2022
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Che J Ngwa *Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.
Mackensie R Gross *Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Jean-Pierre MusabyimanaDivision of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.
Gabriele PradelDivision of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.
Kirk W DeitschDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA kwd2001@med.cornell.edu.ORCID 0000-0002-9183-2480
RWTH Aachen University · DECornell University · US

Funding

Var gene regulation and antigenic variation in malariaR01AI052390 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2002 to 2019
$6.6M
Mechanisms of environmental sensing and responses by malaria parasitesR01AI138499 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2018 to 2022
$3.7M
NIAID NIH HHS R01 AI052390NIAID NIH HHS R01 AI138499
6 · The paper itself

Abstract

The virulence of the malaria parasite

Indexed as

Antigenic VariationAntigens, ProtozoanChromatinEpigenesis, GeneticGene Expression RegulationHistone MethyltransferasesPlasmodium falciparumProtozoan ProteinsTranscriptional ActivationAntigens, ProtozoanChromatinerythrocyte membrane protein 1, Plasmodium falciparumHistone MethyltransferasesProtozoan Proteinsantigenic variationchromatin modificationsepigenetic gene regulationhistone methyltransferasemalaria

Identifiers

PMID33536326
PMCPMC7860991
OpenAlexW3127526669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.