Evidence map›Paper›PMID 33536322›Full record

ArticlemSphere2021

Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model.

Christina L Hutson, Ashley V Kondas, Mathew R Mauldin, Jeffrey B Doty, Irma M Grossi, Clint N Morgan, Sharon Dietz Ostergaard, Christine M Hughes, Yoshinori Nakazawa, Chantal Kling and 5 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 102 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 4 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 4 syntheses or guidelines pooled it, 174 citations in OpenAlex.

  1. Therapeutics for treating mpox in humans.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. A comprehensive overview of monkeypox virus disease.Tropical medicine and health · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. From neglected to notoriety: a review of Mpox clinical features, virology, epidemiology, treatment and prevention strategies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Christina L HutsonPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA zuu6@cdc.gov.ORCID 0000-0001-7998-9728
Ashley V KondasPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Mathew R MauldinPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jeffrey B DotyPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Irma M GrossiChimerix, Durham, North Carolina, USA.
Clint N MorganPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sharon Dietz OstergaardAnimal Resources Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Christine M HughesPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Yoshinori NakazawaPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Chantal KlingPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Brock E MartinPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
James A EllisonPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0003-4492-4857
Darin S CarrollPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Nadia F Gallardo-RomeroPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Victoria A OlsonPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USChimerix (United States) · USOak Ridge Associated Universities · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smallpox, caused by

Indexed as

CytosineMonkeypox virusMpox, MonkeypoxOrganophosphonatesSmallpoxAnimalsAntiviral AgentsBenzamidesDisease Models, AnimalDogsFemaleIsoindolesMalePhthalimidesVariola virusAntiviral AgentsBenzamidesbrincidofovirCytosineIsoindolesOrganophosphonatesPhthalimidestecovirimatanimal modelsexperimental therapeuticsmonkeypoxsmallpoxvirology

Identifiers

PMID33536322
PMCPMC7860987
OpenAlexW3126622270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.