ArticleJournal of clinical microbiology2021
A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.
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In one paragraph
Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Study on the Mechanism of Berberine Reversing MRSA Resistance to β-Lactam Antibiotics by Inhibiting blaZ Expression.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Cefazolin Versus Antistaphylococcal Penicillins in Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2026Review
- Development of a rapid diagnostic test for the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus: Cefinase disk direct (CDD) test.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies.Infectious diseases and therapy · 2026Review
- Article
- Validation of a modified rapid test to detect the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus from bloodstream infections in hospitals from North and Latin America.The Journal of antimicrobial chemotherapy · 2025Article
- NaHCO3 modulates the bla operon and β-lactam susceptibility in borderline oxacillin-resistant Staphylococcus aureus (BORSA).The Journal of antimicrobial chemotherapy · 2025Article
- Discordant β-Lactam Susceptibility in ClinicalMicroorganisms · 2024Article
- Prevalence of the cefazolin inoculum effect (CzIE) in nasal colonizing methicillin-susceptibleAntimicrobial agents and chemotherapy · 2024Article
- Prevalence of the Cefazolin Inoculum Effect (CzIE) in Nasal Colonizing Methicillin-SusceptiblemedRxiv : the preprint server for health sciences · 2024Article
- Clinical significance of cefazolin inoculum effect in serious MSSA infections: a systematic review.JAC-antimicrobial resistance · 2024Review
- Disc Test for Detecting Staphylococcus aureus Strains Producing Type A and Type C β-Lactamases.Microbiology spectrum · 2023Article
- Genomic epidemiology ofMicrobial genomics · 2023Observational
- Prevalence and Characterization of the Cefazolin Inoculum Effect in North American Methicillin-Susceptible Staphylococcus aureus Isolates.Journal of clinical microbiology · 2022Article
- Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients.Open forum infectious diseases · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 3 countries.
Sandra Rincon *Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Lina P Carvajal *Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Sara I Gomez-VillegasCenter for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Aura M EcheverriMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Rafael RiosMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
An DinhCenter for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Claudia PedrozaCenter for Clinical Research and Evidence-Based Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Karen M OrdoñezE.S.E. Hospital Universitario San Jorge de Pereira, Risaralda, Colombia.
Esteban NanniniFacultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.
Zhizeng SunBaylor College of Medicine, Houston, Texas, USA.
Vance G FowlerDivision of Infectious Diseases, Department of Medicine, Duke University, Durham, North Carolina, USA.
Barbara E MurrayCenter for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
William R MillerCenter for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.ORCID 0000-0002-1518-2973
Timothy PalzkillBaylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-5267-0001
Lorena DiazMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Cesar A Arias *Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA caa22@cantab.net reyesjinnethe@unbosque.edu.co.
Jinnethe Reyes *Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia caa22@cantab.net reyesjinnethe@unbosque.edu.co.ORCID 0000-0002-1722-0734
Universidad El Bosque · COThe University of Texas Health Science Center at Houston · USBaylor College of Medicine · USCenter for Clinical Research (United States) · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARDuke University · USTechnological University of Pereira · CO
Funding
BETA-LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCER01AI032956 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Timothy Palzkill · 1992 to 2026
$6.5MInstitutional Career Development CoreKL2TR003168 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, CHARLES C · 2019 to 2023
$4.9MVENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9MThe LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7MBeta Lactamase Mutations in Antibiotic ResistanceR37AI032956 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI PALZKILL, TIMOTHY · 2001 to 2010
$3.3MPOR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5MRole of YxdJK and DAK in the Enterococcal Envelope Stress ResponseK08AI135093 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, WILLIAM R · 2018 to 2022
$929kMolecular basis of the cefazolin inoculum effectR21AI143229 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2019 to 2020
$442kDeveloping a better understanding of expression and function of PBP5-R of Enterococcus faecium for future development of therapeutic modalities for VRE infectionsR21AI133289 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MURRAY, BARBARA E · 2018 to 2019
$439kCharacterization of LiaR from multidrug-resistant E. faeciumR21AI114961 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2015 to 2016
$438kBeta Lactamase Mutations in Antibiotic ResistanceR56AI032956 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI PALZKILL, TIMOTHY · 2016 to 2016
$394kNCATS NIH HHS KL2 TR003168NIAID NIH HHS K08 AI135093NIAID NIH HHS K24 AI121296NIAID NIH HHS R01 AI032956NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI148342NIAID NIH HHS R21 AI114961NIAID NIH HHS R21 AI133289NIAID NIH HHS R21 AI143229NIAID NIH HHS R37 AI032956NIAID NIH HHS R56 AI032956
Abstract
The cefazolin inoculum effect (CzIE) has been associated with therapeutic failures and mortality in invasive methicillin-susceptible
Indexed as
CefazolinStaphylococcal InfectionsAnti-Bacterial AgentsDiagnostic Tests, RoutineHumansLatin AmericaMethicillinMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsCefazolinMethicillinBlaZcefazolin inoculum effectCzIE rapid testhigh inoculum
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.