Evidence map›Paper›PMID 33536234›Full record

ArticleeNeuro

Novel Influences of Sex and

Lydia E Strattan, Daimen R S Britsch, Chris M Calulot, Rachel S J Maggard, Erin L Abner, Lance A Johnson, Warren J Alilain

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Sex andJournal of neurophysiology · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Challenges in Translating Regenerative Therapies for Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lydia E StrattanDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40536.
Daimen R S BritschSpinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536.
Chris M CalulotSpinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536.
Rachel S J MaggardDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40536.
Erin L AbnerSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40504.
Lance A JohnsonSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40504.
Warren J AlilainDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40536 warren.alilain@uky.edu.
University of Kentucky · US

Funding

APOE and the PPP: Glucose Metabolism and Oxidative Stress in Alzheimer's DiseaseR01AG060056 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2018 to 2022
$2.5M
Examining the Effects of the Neuroprotective APOE2 Allele on Peripheral ImmunometabolismR01AG062550 · NIA · UNIVERSITY OF KENTUCKY · PI JOHNSON, LANCE ALLEN · 2019 to 2023
$2.2M
Promoting and understanding recovery of breathing after chronic spinal cord injuryR01NS101105 · NINDS · UNIVERSITY OF KENTUCKY · PI ALILAIN, WARREN JOSEPH · 2017 to 2021
$1.7M
NIA NIH HHS R01 AG060056NIA NIH HHS R01 AG062550NINDS NIH HHS R01 NS101105
6 · The paper itself

Abstract

Spinal cord injuries can abolish both motor and sensory function throughout the body. Spontaneous recovery after injury is limited and can vary substantially between individuals. Despite an abundance of therapeutic approaches that have shown promise in preclinical models, there is currently a lack of effective treatment strategies that have been translated to restore function after spinal cord injury (SCI) in the human population. We hypothesized that sex and genetic background of injured individuals could impact how they respond to treatment strategies, presenting a barrier to translating therapies that are not tailored to the individual. One gene of particular interest is

Indexed as

Sex FactorsSpinal Cord InjuriesAnimalsApolipoproteins EFemaleGenotypeMaleMiceNeuronal PlasticityRecovery of FunctionSpinal CordApoe protein, mouseApolipoproteins Eapolipoprotein Ebreathinggeneticsplasticityspinal cord injury

Identifiers

PMID33536234
PMCPMC7986541
OpenAlexW3126296472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.