Evidence map›Paper›PMID 33536201›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Catecholaminergic Innervation of the Lateral Nucleus of the Cerebellum Modulates Cognitive Behaviors.

Erik S Carlson, Avery C Hunker, Stefan G Sandberg, Timothy M Locke, Julianne M Geller, Abigail G Schindler, Steven A Thomas, Martin Darvas, Paul E M Phillips, Larry S Zweifel

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  9. Characterization of direct Purkinje cell outputs to the brainstem.bioRxiv : the preprint server for biology · 2024
    Article
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  11. Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Erik S CarlsonDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195 esc1@uw.edu.
Avery C HunkerDepartment of Pharmacology, University of Washington, Seattle, Washington 98195.
Stefan G SandbergDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195.
Timothy M LockeDepartment of Pharmacology, University of Washington, Seattle, Washington 98195.
Julianne M GellerGeriatric Research, Education and Clinical Center, Veteran's Affairs Medical Center, Puget Sound, Seattle, Washington 98108.
Abigail G SchindlerGeriatric Research, Education and Clinical Center, Veteran's Affairs Medical Center, Puget Sound, Seattle, Washington 98108.
Steven A ThomasDepartment of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Martin DarvasDepartment of Pathology, University of Washington, Seattle, Washington 98195.
Paul E M PhillipsDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195.
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195.
University of Washington · USGeriatric Research Education and Clinical Center · USUniversity of Pennsylvania · USUniversity of Puget Sound · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Neural mechanisms regulating cocaine consumptionR37DA051686 · NIDA · UNIVERSITY OF WASHINGTON · PI PHILLIPS, PAUL E. M. · 2020 to 2024
$2.5M
Catecholaminergic Signaling in Normal Cognition, Aging and Models of Alzheimer's DiseaseRF1AG066905 · NIA · UNIVERSITY OF PENNSYLVANIA · PI THOMAS, STEVEN A · 2020 to 2020
$2.5M
Genetic Dissection of Catecholaminergic Innervation of the Cognitive CerebellumR01MH116883 · NIMH · UNIVERSITY OF WASHINGTON · PI CARLSON, ERIK SEAN · 2018 to 2022
$2.0M
Inducible recombination and gene expression in specific neurotransmitter systemsR01MH080333 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI THOMAS, STEVEN A · 2008 to 2012
$1.8M
Genetic Dissection of Cerebellar Circuitry in Cognitive and Affective BehaviorK08MH104281 · NIMH · UNIVERSITY OF WASHINGTON · PI CARLSON, ERIK SEAN · 2014 to 2017
$727k
Cell type-specific calcium imaging during hippocampus-dependent memoryR21MH098177 · NIMH · UNIVERSITY OF WASHINGTON · PI ZWEIFEL, LARRY S · 2012 to 2013
$417k
NIA NIH HHS RF1 AG066905NIDA NIH HHS P30 DA048736NIDA NIH HHS R37 DA051686NIGMS NIH HHS T32 GM007270NIMH NIH HHS K08 MH104281NIMH NIH HHS R01 MH080333NIMH NIH HHS R01 MH116883NIMH NIH HHS R21 MH098177
6 · The paper itself

Abstract

The cerebellum processes neural signals related to rewarding and aversive stimuli, suggesting that the cerebellum supports nonmotor functions in cognitive and emotional domains. Catecholamines are a class of neuromodulatory neurotransmitters well known for encoding such salient stimuli. Catecholaminergic modulation of classical cerebellar functions have been demonstrated. However, a role for cerebellar catecholamines in modulating cerebellar nonmotor functions is unknown. Using biochemical methods in male mice, we comprehensively mapped TH

Indexed as

CognitionAnimalsCerebellar NucleiFearLocus CoeruleusMaleMemory, Short-TermMiceNeural PathwaysNeuronsNorepinephrineTyrosine 3-MonooxygenaseNorepinephrineTyrosine 3-Monooxygenasecerebellumfear conditioningnorepinephrinetyrosine hydroxylasevoltammetryworking memory

Identifiers

PMID33536201
PMCPMC8051686
OpenAlexW3128507288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.