ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Reduced Motivation in Perinatal Fluoxetine-Treated Mice: A Hypodopaminergic Phenotype.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing neurons of the lateral and basolateral amygdalar nuclei.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats.Pharmacological reports : PR · 2025Article
- Dopamine D2 receptor agonists prevent impairment of maternal care in lipopolysaccharide-induced postpartum depression model mice.The Journal of veterinary medical science · 2025Article
- Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans.Nature communications · 2025Article
- Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala.Neuron · 2021Article
- Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals.Alcohol (Fayetteville, N.Y.) · 2021Article
- Serotonergic regulation of the dopaminergic system: Implications for reward-related functions.Neuroscience and biobehavioral reviews · 2021Review
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Authors and funding
11 authors at 3 institutions in 1 country.
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Abstract
Early life is a sensitive period, in which enhanced neural plasticity allows the developing brain to adapt to its environment. This plasticity can also be a risk factor in which maladaptive development can lead to long-lasting behavioral deficits. Here, we test how early-life exposure to the selective-serotonin-reuptake-inhibitor (SSRI), fluoxetine, affects motivation, and dopaminergic signaling in adulthood. We show for the first time that mice exposed to fluoxetine in the early postnatal period exhibit a reduction in effort-related motivation. These mice also show blunted responses to amphetamine and reduced dopaminergic activation in a sucrose reward task. Interestingly, we find that the reduction in motivation can be rescued in the adult by administering bupropion, a dopamine-norepinephrine reuptake inhibitor used as an antidepressant and a smoke cessation aid but not by fluoxetine. Taken together, our studies highlight the effects of early postnatal exposure of fluoxetine on motivation and demonstrate the involvement of the dopaminergic system in this process.
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