Evidence map›Paper›PMID 33536141›Full record

ReviewTrends in immunology2021

The Roles of T cells in Bladder Pathologies.

Jianxuan Wu, Soman N Abraham

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. The emerging roles of exosomal long non-coding RNAs in bladder cancer.Journal of cellular and molecular medicine · 2022
    Review
  9. Bladder infection with uropathogenicAmerican journal of physiology. Renal physiology · 2022
    Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jianxuan WuDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Soman N AbrahamDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore. Electronic address: soman.abraham@duke.edu.
Duke Medical Center · USNational University of Singapore · SG

Funding

Loss of Bladder Control Following Recurrent InfectionsR01DK121969 · NIDDK · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N · 2020 to 2023
$1.6M
Aberrant remodeling of bladder following infectionR01DK121032 · NIDDK · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N · 2019 to 2022
$1.6M
Combatting Bladder Cancer by Inducing Epithelial TurnoverR21CA223093 · NCI · DUKE UNIVERSITY · PI ABRAHAM, SOMAN N · 2019 to 2020
$372k
NCI NIH HHS R21 CA223093NIDDK NIH HHS R01 DK121032NIDDK NIH HHS R01 DK121969
6 · The paper itself

Abstract

T lymphocytes play important roles in the skin and mucosal surfaces such as the gut and lung. Until recently the contributions of T cells to mammalian bladder immunity were largely unknown. With newer techniques, including single-cell RNA sequencing and reporter mice, an understanding is emerging of T cell roles in bladder diseases (bacterial infections, bladder cancer, chronic inflammation). In these pathologies, many bladder T cell responses can be harmful to the host through suboptimal clearance of bacteria or cancer cells, or by modulating autoinflammation. Recent findings suggest that T cell behavior might be influenced by resident T cell interactions with the bladder microbiota and other immunostimulants. Thus, regulating bladder T cell functions could emerge as a putative immunotherapy to treat some bladder diseases.

Indexed as

MicrobiotaT-LymphocytesAnimalsBacteriaMiceMucous MembraneUrinary Bladder

Identifiers

PMID33536141
PMCPMC7914211
OpenAlexW3126207632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.