Evidence map›Paper›PMID 33535957›Full record

ReviewCurrent neuropharmacology2021

Exosomes as a Promising Therapeutic Strategy for Peripheral Nerve Injury.

Tianhao Yu, Yingxi Xu, Muhammad Arslan Ahmad, Rabia Javed, Haruo Hagiwara, Xiaohong Tian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tianhao YuThe VIP Department, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.
Yingxi XuDepartment of Clinical Nutrition, Shengjing Hospital of China Medical University, Shenyang, China.
Muhammad Arslan AhmadDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Rabia JavedDepartment of Tissue Engineering, China Medical University, Shenyang, China.
Haruo HagiwaraDepartment of Anatomy and Cell Biology, Teikyo University School of Medicine, Tokyo, Japan.
Xiaohong TianDepartment of Tissue Engineering, China Medical University, Shenyang, China.

Funding

Liaoning-Shenyang National Laboratory for Materials Science 2019JH3/30100022National Key R&D Program of China 2017YFA0105802National Natural Science Foundation of China 81771351, 31600793
6 · The paper itself

Abstract

Peripheral nerve injury has a high incidence and often leads to severe losses of sensory and motor functions in the afflicted limb. Autologous nerve grafts are widely accepted as the gold standard for peripheral nerve repair, but the presence of inherent drawbacks dramatically reduces their usability. Numerous tissue engineering nerve grafts are developed as alternatives to autologous nerve grafts, and a variety of cells and neurotrophic factors are introduced into these grafts for improvement. However, they are still difficult to obtain satisfactory clinical results. Peripheral nerve regeneration following injury remains a significant challenge for researchers and clinicians. Exosomes are extracellular membranous nanovesicles that are secreted by most cells. As the key players of intercellular communication, exosomes play a fundamental role in the physiological and pathological processes of the nervous system. Accumulating evidence has suggested that exosomes can exert neurotherapeutic effects via mediating axonal regrowth, Schwann cell activation, vascular regeneration, and inflammatory regulation. Exosomes are emerging as a promising approach for treating peripheral nerve injury. Furthermore, they also provide possibilities for enhancing the repairing capacity of various nerve grafts. This review primarily highlights the regenerative effects of exosomes on peripheral nerve injury. The exosomes from distinct sources reported so far in the literature are summarized to understand their roles in the process of nerve repair. Moreover, the challenges that must be addressed in their clinical transformation are outlined as well. This review also provides further insight into the potential application of exosomes for peripheral nerve repair.

Indexed as

ExosomesPeripheral Nerve InjuriesAxonsHumansNerve RegenerationSchwann Cellsaxonal regrowthExosomeinflammationnerve regenerationperipheral nerve injurySchwann cellvascular regeneration.

Identifiers

PMID33535957
PMCPMC9185764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.