Evidence map›Paper›PMID 33535892›Full record

ArticleChannels (Austin, Tex.)2021

Expression defect of the rare variant/Brugada mutation R1512W depends upon the SCN5A splice variant background and can be rescued by mexiletine and the common polymorphism H558R.

Rou-Mu Hu, Evelyn J Song, David J Tester, Isabelle Deschenes, Michael J Ackerman, Jonathan C Makielski, Bi-Hua Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Biophysical mechanisms of myocardium sodium channelopathies.Pflugers Archiv : European journal of physiology · 2024
    Review
  4. Prokaryotic voltage-gated sodium channels are more effective than endogenous NaAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rou-Mu HuDepartment of Cardiology, Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University , Beijing, China.
Evelyn J SongDepartment of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
David J TesterDepartments of Medicine, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester , MN, USA.
Isabelle DeschenesDepartment of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, Frick Center for Heart Failure and Arrhythmia, the Ohio State University , Columbus, OH, USA.
Michael J AckermanDepartments of Medicine, Pediatrics, and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester , MN, USA.
Jonathan C MakielskiDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin , Madison, WI, USA.
Bi-Hua TanDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin , Madison, WI, USA.
University of Wisconsin–Madison · USMayo Clinic · USJohns Hopkins University · US

Funding

Sodium Channels and Cardiac ArrhythmiasR01HL094450 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2010 to 2022
$4.0M
Cellular &Clinical Phenotypes of Novel SCN5a MutationsR01HL071092 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MAKIELSKI, JONATHAN C · 2003 to 2011
$3.1M
Transcriptional Regulation of Ion Channels in Heart Failure and ArrhythmiasR01HL132520 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2016 to 2019
$2.4M
The cardiac Na current macromolecular complex and role in arrhythmia mechanismR56HL071092 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MAKIELSKI, JONATHAN C · 2014 to 2014
$376k
NHLBI NIH HHS R01 HL071092NHLBI NIH HHS R01 HL094450NHLBI NIH HHS R01 HL132520NHLBI NIH HHS R56 HL071092
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brugada SyndromeMexiletineMutationNAV1.5 Voltage-Gated Sodium ChannelHEK293 CellsHumansPolymorphism, GeneticMexiletineNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humancommon polymorphismmexiletineSCN5Asplice variant

Identifiers

PMID33535892
PMCPMC7872018
OpenAlexW3126714586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.