Evidence map›Paper›PMID 33535789›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Early Detection of Aortic Degeneration in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-Enhanced Computed Tomography.

Ketan B Ghaghada, Pingping Ren, Laxman Devkota, Zbigniew Starosolski, Chen Zhang, Deborah Vela, Igor V Stupin, Eric A Tanifum, Ananth V Annapragada, Ying H Shen and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Transport across the thoracic aortic wall: implications for aneurysm pathobiology, diagnosis, and treatment.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  3. Review
  4. Polymeric Nanomaterials for Atherosclerosis Diagnosis and Treatment.Polymer science & technology (Washington, D.C.) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Progress in murine models of ruptured abdominal aortic aneurysm.Frontiers in cardiovascular medicine · 2022
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ketan B GhaghadaEdward B. Singleton Department of Radiology, Texas Children's Hospital, Houston (K.B.G., L.D., Z.S., I.V.S., E.A.T., A.V.A.).
Pingping RenDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery (P.R., C.Z., Y.H.S., S.A.L.), Baylor College of Medicine, Houston, TX.
Laxman DevkotaEdward B. Singleton Department of Radiology, Texas Children's Hospital, Houston (K.B.G., L.D., Z.S., I.V.S., E.A.T., A.V.A.).
Zbigniew StarosolskiEdward B. Singleton Department of Radiology, Texas Children's Hospital, Houston (K.B.G., L.D., Z.S., I.V.S., E.A.T., A.V.A.).
Chen ZhangDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery (P.R., C.Z., Y.H.S., S.A.L.), Baylor College of Medicine, Houston, TX.
Deborah VelaDepartment of Cardiovascular Pathology Research (D.V.), Texas Heart Institute, Houston.
Igor V StupinEdward B. Singleton Department of Radiology, Texas Children's Hospital, Houston (K.B.G., L.D., Z.S., I.V.S., E.A.T., A.V.A.).
Eric A TanifumEdward B. Singleton Department of Radiology, Texas Children's Hospital, Houston (K.B.G., L.D., Z.S., I.V.S., E.A.T., A.V.A.).
Ananth V AnnapragadaEdward B. Singleton Department of Radiology, Texas Children's Hospital, Houston (K.B.G., L.D., Z.S., I.V.S., E.A.T., A.V.A.).
Ying H ShenCardiovascular Research Institute (K.B.G., A.V.A., Y.H.S., S.A.L.), Baylor College of Medicine, Houston, TX.
Scott A LeMaireCardiovascular Research Institute (K.B.G., A.V.A., Y.H.S., S.A.L.), Baylor College of Medicine, Houston, TX.
Baylor College of Medicine · USHouston Methodist · USMichael E. DeBakey VA Medical Center · USTexas Children's Hospital · US

Funding

Targeting ER Stress To Treat Aortic Aneurysms and DissectionsR01HL131980 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2016 to 2019
$1.7M
Targeting the Inflammasome to Prevent Thoracic Aortic Aneurysms and DissectionsR01HL127111 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A · 2016 to 2019
$1.6M
Mitochondrial Damage-Induced Necroptotic Cell Death in SporadicAscending Thoracic Aortic Aneurysms and DissectionsR01HL143359 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL127111NHLBI NIH HHS R01 HL131980NHLBI NIH HHS R01 HL143359
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AortographyComputed Tomography AngiographyContrast MediaNanoparticlesTriiodobenzoic AcidsX-Ray MicrotomographyAngiotensin IIAnimalsAortaAortic AneurysmAortic DissectionAortic RuptureDiet, High-FatDilatation, PathologicDisease Models, AnimalDisease ProgressionAngiotensin IIContrast MediaiodixanolTriiodobenzoic Acidsaneurysm, dissectionangiotensin IIaortic aneurysmcontrast mediananoparticles

Identifiers

PMID33535789
PMCPMC7990703
OpenAlexW3126679229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.