Evidence map›Paper›PMID 33535685›Full record

ArticleToxins2021

Oral Sub-chronic Ochratoxin A Exposure Induces Gut Microbiota Alterations in Mice.

María Izco, Ariane Vettorazzi, Maria de Toro, Yolanda Sáenz, Lydia Alvarez-Erviti

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  10. The intestinal microbiota as mediators between dietary contaminants and host health.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

María IzcoLaboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain.ORCID 0000-0003-4807-6779
Ariane VettorazziMITOX Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-9182-8417
Maria de ToroCenter for Biomedical Research of La Rioja (CIBIR), Genomics and Bioinformatics Core Facility, 26006 Logroño Spain.
Yolanda SáenzMolecular Microbiology Area, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain.ORCID 0000-0002-2457-4258
Lydia Alvarez-ErvitiLaboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain.ORCID 0000-0002-1238-9442
Center for Biomedical Research of La Rioja · ESNavarre Institute of Health Research · ES

Funding

European Regional Development Fund 6FRSSABC008
6 · The paper itself

Abstract

Gut microbiota plays crucial roles in maintaining host health. External factors, such as diet, medicines, and environmental toxins, influence the composition of gut microbiota. Ochratoxin A (OTA) is one of the most prevalent and relevant mycotoxins and is a highly abundant food and animal feed contaminant. In the present study, we aimed to investigate OTA gut microbiome toxicity in mice sub-chronically exposed to low doses of OTA (0.21, 0.5, and 1.5 mg/kg body weight) by daily oral gavage for 28 days. Fecal microbiota from control and OTA-treated mice was analyzed using 16S ribosomal RNA (rRNA) gene sequencing followed by metagenomics. OTA exposure caused marked changes in gut microbial community structure, including the decrease in the diversity of fecal microbiota and the relative abundance of

Indexed as

Administration, OralAnimalsBacteriaDysbiosisFecesGastrointestinal MicrobiomeIntestinesMaleMiceMice, Inbred BALB COchratoxinsRibotypingTime FactorsToxicity Tests, Subchronicochratoxin AOchratoxinsgut microbiotamicemycotoxinochratoxin Atoxicity

Identifiers

PMID33535685
PMCPMC7912851
OpenAlexW3129043721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.