ArticleJournal of clinical medicine2021
External Validation of Surrogate Indices of Fatty Liver in the General Population: the Bagnacavallo Study.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Diagnostic value of serological scores for the detection of liver steatosis in people with HIV in low- and middle-income countries.AIDS (London, England) · 2026Article
- Using machine learning to identify the most important predictors of fatty liver index in healthy young Taiwanese men.Scientific reports · 2026Article
- Thyroid Stimulating Hormone Levels Are Related to Fatty Liver Indices Independently of Free Thyroxine: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Association between surrogate indices of fatty liver and the risk of colorectal cancer: a cross-sectional United States study.Translational cancer research · 2025Article
- [Predictive factors for MASLD in type 2 diabetes: 1 year follow-up study].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- External Validation of Serologic Scores for the Detection of Liver Steatosis Among People With HIV.Open forum infectious diseases · 2024Article
- Liver Fat Scores for Noninvasive Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease in Epidemiological and Clinical Studies.Journal of clinical and translational hepatology · 2023Review
- Associations of non-invasive indices of liver steatosis and fibrosis with progressive kidney impairment in adults with type 2 diabetes.Acta diabetologica · 2023Article
- Diagnostic ability using fatty liver and metabolic markers for metabolic-associated fatty liver disease stratified by metabolic/glycemic abnormalities.Journal of diabetes investigation · 2023Article
- Advances in the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2023Review
- Surveillance of the progression and assessment of treatment endpoints for nonalcoholic steatohepatitis.Clinical and molecular hepatology · 2023Review
- Non-alcoholic fatty liver disease and the risk of fibrosis in Italian primary care services: GPS-NAFLD Study: GPS-NAFLD Study.Liver international : official journal of the International Association for the Study of the Liver · 2022Article
- Association between Mediterranean Diet and Fatty Liver in Women with Overweight and Obesity.Nutrients · 2022Article
- Associations between non-alcoholic fatty liver disease and cognitive impairment and the effect modification of inflammation.Scientific reports · 2022Article
- Comparison of the Diagnostic Performance of Steatosis Indices for Discrimination of CT-Diagnosed Metabolic Dysfunction-Associated Fatty Liver Disease.Metabolites · 2022Article
- Association of Insulin Resistance with Vascular Ageing in a General Caucasian Population: An EVA Study.Journal of clinical medicine · 2021Article
- Non-alcoholic Fatty Liver Disease and COVID-19 Susceptibility and Outcomes: a Korean Nationwide Cohort.Journal of Korean medical science · 2021Article
- Development and Internal Validation of Fatty Liver Prediction Models in Obese Children and Adolescents.Journal of clinical medicine · 2021Article
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
We externally validated the fatty liver index (FLI), the lipid accumulation product (LAP), the hepatic steatosis index (HSI), and the Zhejiang University index (ZJU) for the diagnosis of fatty liver (FL) and non-alcoholic fatty liver disease (NAFLD) in the general population. The validation was performed on 2159 citizens of the town of Bagnacavallo (Ravenna, Italy). Calibration was evaluated by calculating the calibration slope and intercept and by inspecting calibration plots; discrimination was evaluated using the c-statistic. The average calibration slope was 1 and the average intercept was 0 for all combinations of outcomes and indices. For the diagnosis of FL, the c-statistic was 0.85 for FLI, 0.83 for ZJU, 0.82 for HSI, and 0.80 for LAP; for the diagnosis of NAFLD, the c-statistic was 0.77 for FLI, 0.76 for ZJU, 0.75 for HSI, and 0.74 for LAP. All indices were strongly correlated with each other. In conclusion, FLI, LAP, HSI, and ZJU perform similarly well to diagnose FL and NAFLD in the Bagnacavallo population, even if FLI has a small advantage as discrimination is concerned.
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