ReviewJournal of clinical medicine2021
Salivary Biomarkers of Stress, Anxiety and Depression.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 113 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Well-being Biomarkers and Psychological Functioning of Adult Patients During Chemotherapy Treatment: the Effects of Hospital Clowns and Hosting Conditions
Evaluation Of Stress Levels Of A Group Of Pediatric Dentist During Laryngeal Mask, Deep Sedation And General Anesthesia Procedures
Who cites it
113 citing papers in PubMed, 4 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- Emotion regulation in autistic adolescents: a mixed methods systematic review.Journal of neurodevelopmental disorders · 2025Pooled it
- Opiorphin as a biomarker of orofacial conditions: a meta-analysis.Scientific reports · 2023Pooled it
- Music listening and stress recovery in healthy individuals: A systematic review with meta-analysis of experimental studies.PloS one · 2022Pooled it
- Pooled it
- Effects of different dental local anesthesia techniques on salivary cortisol and secretory immunoglobulin a in pediatric patients: a randomized controlled clinical study.Clinical oral investigations · 2026Trial
- Acute pre-exercise oral intake of cacao polyphenols attenuates central fatigue development during sustained low-intensity ankle dorsiflexion exercise in healthy young male adults.Physiological reports · 2026Trial
- Preoperative care through aromatherapy and music therapy: comparative study on anxiety and physiological indices in mastectomy candidates.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Trial
- Electroacupuncture and acupuncture in the treatment of anxiety - A double blinded randomized parallel clinical trial.Complementary therapies in clinical practice · 2022Trial
- Feasibility and safety of combined touch care and aromatherapy in hospitalized patients with thoracic malignancies: A prospective single-arm study.Asia-Pacific journal of oncology nursing · 2026Article
- Comparative Effects of Behavioral Analysis Therapy of Feelings and Brief Focal Psychotherapy: Protocol for a Randomized Controlled Assessor-Blinded Clinical Trial.Medical sciences (Basel, Switzerland) · 2026Article
- Article
- Comparison of classic statistical methods and machine learning approaches to classify readiness.Bioinformatics (Oxford, England) · 2026Article
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Salivary opiorphin as a potential non-invasive biomarker for dental anxiety.BMC oral health · 2026Article
- Salivary biomarkers in burning mouth syndrome: an umbrella review of systematic reviews.BMC oral health · 2026Article
- Stress Accelerates Depressive-Like Behaviors through Increase of Notch2 Expression in N141I Mutation Presenilin-2 Transgenic Mice.Biomolecules & therapeutics · 2026Article
- Maternal Salivary Glutamate Concentrations in Cesarean Delivery: A Prospective Comparison Between Spinal and General Anesthesia.Life (Basel, Switzerland) · 2026Article
- Metabolomics of mouth-rinsed water for assessing psychophysiological stress in office workers.Scientific reports · 2026Article
- Stability of salivary cortisol, alpha-amylase, and chromogranin A after long-term storage.Scientific reports · 2026Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress, anxiety and depressive disorders are often characterized by the activation of the stress axis, which results in similar symptoms at some point in these disorders. These disorders are closely related to each other-they occur simultaneously or follow one another. The diagnosis of stress, anxiety and depression is not a perfect procedure currently-it is based on patient observation and an interview with the patient and their family. There are no laboratory tests that would dispel the doubts of the doctor making the diagnosis and allow the appropriate treatment to be implemented as soon as possible. Therefore, this study will review the components of saliva that could be helpful in the quick diagnosis of stress, anxiety and/or depression. Such potential salivary biomarkers could also be useful in monitoring the effectiveness of pharmacological treatment prescribed by a psychiatrist. The following are promising salivary biomarkers of stress, anxiety or depression: cortisol, immunoglobulin A (sIgA), lysozyme, melatonin, α-amylase (sAA), chromogranin A (CgA) and fibroblast growth factor 2 (FGF-2). To the best valuable potential salivary markers of stress, we can include cortisol, lysozyme, sAA and CgA. To differentiate depression from stress, salivary cortisol and melatonin can be helpful. Fluctuations in the concentrations of the above-mentioned substances in saliva indicate a particularly strong relationship with typical human psychological problems, such as stress, depression or anxiety.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.