ArticleJournal of clinical medicine2021
What Are the Expectations for Cardiac Resynchronization Therapy? A Validation of Two Response Definitions.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Target doses of guideline-directed medical therapeutic agents predicts response to cardiac resynchronization therapy.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Deep Learning-Based Prediction Model for Cardiac Resynchronization Therapy Responders Using Electrocardiogram Data.Journal of cardiovascular electrophysiology · 2026Article
- Efficacy of leadless left ventricular endocardial stimulation for non-responders to cardiac resynchronization therapy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Early occurrence of heart failure hospitalization or ventricular arrhythmia re-define the long-term prognosis after CRT.ESC heart failure · 2025Article
- The Role of Cardiac Resynchronization Therapy in Heart Failure: A Narrative Review.Health science reports · 2025Article
- Harmonizing Heartbeats: The Mosaic of Cardiac Resynchronization Therapy Responders-A Comprehensive Exploration of Diverse Criteria and Predictors.Journal of clinical medicine · 2024Article
- The Impact of Intravenous Ferric Carboxymaltose on Reverse Electrical Remodeling Following Cardiac Resynchronization Therapy.Acta Cardiologica Sinica · 2024Article
- Predictors of Higher Frequency of Atrial Fibrillation in Patients with Cardiac Resynchronization Therapy.Medicina (Kaunas, Lithuania) · 2023Article
- Cardiac reverse remodelling by imaging parameters with recent changes to guideline medical therapy in heart failure.ESC heart failure · 2023Review
- Role of monocytes and dendritic cells in cardiac reverse remodelling after cardiac resynchronization therapy.BMC cardiovascular disorders · 2023Article
- Outcomes following cardiac resynchronisation therapy in older people.Age and ageing · 2023Article
- Special Issue: Latest Advances in Delivery and Outcomes of Cardiac Resynchronization Therapy and Conduction System Pacing.Journal of clinical medicine · 2023Article
- Review
- Hemodynamic Effects of Sacubitril/Valsartan in Patients with Reduced Left Ventricular Ejection Fraction Over 24 Months: A Retrospective Study.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022Article
- Clinical significance of the albumin-bilirubin score in patients with heart failure undergoing cardiac resynchronization therapy.Heart and vessels · 2022Article
- Fifteen-Year Differences in Indications for Cardiac Resynchronization Therapy in International Guidelines-Insights from the Heart Failure Registries of the European Society of Cardiology.Journal of clinical medicine · 2022Article
- Prognostic value of the MELD-XI score in patients undergoing cardiac resynchronization therapy.ESC heart failure · 2022Article
- Prognostic importance of the Controlling Nutritional Status (CONUT) score in patients undergoing cardiac resynchronisation therapy.Open heart · 2021Observational
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe definition of response to cardiac resynchronization therapy (CRT) varies across clinical trials. There are two main definitions, i.e., echocardiographic response and functional response. We assessed which definition was more reasonable.
methodsIn this study of 260 patients who had undergone CRT, an echocardiographic response was defined as a reduction in a left ventricular end-systolic volume of greater than or equal to 15% or an improvement in left ventricular ejection fraction of greater than or equal to 5%. A functional response was defined as an improvement of at least one class category in the New York Heart Association functional classification. We assessed the response to CRT at 6 months after device implantation, based on each definition, and investigated the relationship between response and clinical outcomes.
resultsThe echocardiographic response rate was 74.2%. The functional response rate was 86.9%. Non-responder status, based on both definitions, was associated with higher all-cause mortality. Cardiac death was only associated with functional non-responder status (hazard ratio (HR) 2.65, 95% confidence interval (CI) 1.19-5.46,
conclusionAfter CRT implantation, the functional response definition of CRT response is associated with a higher response rate and better clinical outcomes than that of the echocardiographic response definition, and therefore it is reasonable to use the functional definition to assess CRT response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.