Evidence map›Paper›PMID 33535574›Full record

ReviewCells2021

Mesenchymal Stem Cells for Mitigating Radiotherapy Side Effects.

Kai-Xuan Wang, Wen-Wen Cui, Xu Yang, Ai-Bin Tao, Ting Lan, Tao-Sheng Li, Lan Luo

Abstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Article
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  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. In Regard to Smart et al.Advances in radiation oncology · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kai-Xuan WangSchool of Medical Technology, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou City 221004, China.
Wen-Wen CuiSchool of Medical Technology, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou City 221004, China.
Xu YangSchool of Medical Technology, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou City 221004, China.
Ai-Bin TaoDivision of Cardiology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang City 212132, China.
Ting LanSchool of Medical Technology, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou City 221004, China.
Tao-Sheng LiDepartment of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.ORCID 0000-0002-7653-8873
Lan LuoSchool of Medical Technology, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou City 221004, China.ORCID 0000-0001-7549-9852

Funding

Grant-in-Aid from the Ministry of Education, Science, Sports, Culture and Technology, Japan 17H04265, 17F17425National Natural Science Foundation of China 81802086, 81802063, 81971817Natural Science Foundation of Jiangsu Province BK20180995Specialized Research Fund for Senior Personnel Program of Xuzhou Medical University D2019028,D2017022Young Science and Technology Innovation Team of Xuzhou Medical University TD202005
6 · The paper itself

Abstract

Radiation therapy for cancers also damages healthy cells and causes side effects. Depending on the dosage and exposure region, radiotherapy may induce severe and irreversible injuries to various tissues or organs, especially the skin, intestine, brain, lung, liver, and heart. Therefore, promising treatment strategies to mitigate radiation injury is in pressing need. Recently, stem cell-based therapy generates great attention in clinical care. Among these, mesenchymal stem cells are extensively applied because it is easy to access and capable of mesodermal differentiation, immunomodulation, and paracrine secretion. Here, we summarize the current attempts and discuss the future perspectives about mesenchymal stem cells (MSCs) for mitigating radiotherapy side effects.

Indexed as

Cell- and Tissue-Based TherapyHumansMesenchymal Stem CellsNeoplasmsRadiation Injuriesmesenchymal stem cellsradiation-induced injuryradiotherapy

Identifiers

PMID33535574
PMCPMC7912747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.