ReviewPathogens (Basel, Switzerland)2021
Clinical Implications of Polymicrobial Synergism Effects on Antimicrobial Susceptibility.
Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Machine Learning Approaches for Microorganism Identification, Virulence Assessment, and Antimicrobial Susceptibility Evaluation Using DNA Sequencing Methods: A Systematic Review.Molecular biotechnology · 2025Pooled it
- High mortality rate and restricted mobility in above knee amputation following periprosthetic joint infection after total knee arthroplasty: A systematic review.Archives of orthopaedic and trauma surgery · 2024Pooled it
- 2-Quinolone-1,2,3-triazole-benzofuran-N-acylhydrazone hybrids as antiviral and antimicrobial agents: synthesis, in vitro screening and molecular modeling.Molecular diversity · 2026Article
- Assessing the impact of bacteremia and antibiotic resistance on mortality in patients with monomicrobial and polymicrobial Escherichia coli necrotizing fasciitis.BMC infectious diseases · 2026Article
- Metabolism-Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Gastrointestinal infection caused by five different strains of Aeromonas caviae and one of Aeromonas veronii: case report and review of the literature.BMC infectious diseases · 2026Review
- "Bacterial aetiology in the lower respiratory tract of TB-negative patients with respiratory symptoms: implications for tuberculosis control in Ghana".BMC microbiology · 2026Article
- Bacterial co-detection is associated with higher multidrug-resistantJAC-antimicrobial resistance · 2026Article
- Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.Pathogens (Basel, Switzerland) · 2025Article
- Host niche-specific challenges hindering the treatment of polymicrobial infections.Journal of bacteriology · 2025Review
- Risk Factors for Hospital Readmission Following Outpatient Parenteral Antimicrobial Therapy (OPAT).Infectious diseases and therapy · 2025Article
- Cross-kingdom pathogen detection via duplex universal PCR and high-resolution melt.Biosensors & bioelectronics · 2025Article
- Molecular structural arrangement in quorum sensing and bacterial metabolic production.World journal of microbiology & biotechnology · 2025Review
- Pooled Antibiotic Susceptibility Testing for Polymicrobial UTI Performs Within CLSI Validation Standards.Antibiotics (Basel, Switzerland) · 2025Article
- Selection for florfenicol resistance at sub-MIC concentrations in Pasteurella multocida.PloS one · 2025Article
- Effects of Several Bile Acids on the Production of Virulence Factors byLife (Basel, Switzerland) · 2024Article
- Pooled Antibiotic Susceptibility Testing Performs Within CLSI Standards for Validation When Measured Against Broth Microdilution and Disk Diffusion Antibiotic Susceptibility Testing of Cultured Isolates.Antibiotics (Basel, Switzerland) · 2024Article
- Comparative analysis of the postadmission and antemortem oropharyngeal and rectal swab microbiota of ICU patients.Scientific reports · 2024Article
- Article
- Convergent evolution in toxin detection and resistance provides evidence for conserved bacterial-fungal interactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the development of next generation sequencing technologies in recent years, it has been demonstrated that many human infectious processes, including chronic wounds, cystic fibrosis, and otitis media, are associated with a polymicrobial burden. Research has also demonstrated that polymicrobial infections tend to be associated with treatment failure and worse patient prognoses. Despite the importance of the polymicrobial nature of many infection states, the current clinical standard for determining antimicrobial susceptibility in the clinical laboratory is exclusively performed on unimicrobial suspensions. There is a growing body of research demonstrating that microorganisms in a polymicrobial environment can synergize their activities associated with a variety of outcomes, including changes to their antimicrobial susceptibility through both resistance and tolerance mechanisms. This review highlights the current body of work describing polymicrobial synergism, both inter- and intra-kingdom, impacting antimicrobial susceptibility. Given the importance of polymicrobial synergism in the clinical environment, a new system of determining antimicrobial susceptibility from polymicrobial infections may significantly impact patient treatment and outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.