Evidence map›Paper›PMID 33535452›Full record

ArticleBiomedicines2021

Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis.

Nour Eissa, Omar Elgazzar, Hayam Hussein, Geoffrey N Hendy, Charles N Bernstein, Jean-Eric Ghia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Nour EissaDepartment of Immunology, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.ORCID 0000-0002-3484-6720
Omar ElgazzarDepartment of Immunology, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Hayam HusseinNational Research Centre, Department of Parasitology and Animal Diseases, Veterinary Research Division, Giza 12622, Egypt.
Geoffrey N HendyMetabolic Disorders and Complications, McGill University Health Centre-Research Institute, Departments of Medicine, Physiology, and Human Genetics, McGill University, Montreal, QC H4A 3J1, Canada.ORCID 0000-0002-8050-1192
Charles N BernsteinSection of Gastroenterology, Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Jean-Eric GhiaDepartment of Immunology, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Children's Hospital Research Institute of Manitoba · CAUniversity of Manitoba · CAMcGill University Health Centre · CANational Research Centre · EG

Funding

CIHR 395678
6 · The paper itself

Abstract

Ulcerative colitis (UC) is characterized by modifying alternatively activated macrophages (AAM) and epithelial homeostasis. Chromogranin-A (CHGA), released by enterochromaffin cells, is elevated in UC and is implicated in inflammation progression. CHGA can be cleaved into several derived peptides, including pancreastatin (PST), which is involved in proinflammatory mechanisms. Previously, we showed that the deletion of

Indexed as

alternatively activated macrophageschromogranin-Agut hormonesintestinal epithelial cellsmacrophagesmucosal drug actionpancreastatinproinflammatory peptides

Identifiers

PMID33535452
PMCPMC7912769
OpenAlexW3127674693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.