Evidence map›Paper›PMID 33535024›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.

Brian Hallmark, Ganesa Wegienka, Suzanne Havstad, Dean Billheimer, Dennis Ownby, Eneida A Mendonca, Lisa Gress, Debra A Stern, Jocelyn Biagini Myers, Gurjit K Khurana Hershey and 11 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025
    Pooled it
  2. Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  3. Review
  4. Article
  5. Risk Factors and Mechanisms Leading to Preschool Recurrent Wheeze and Asthma.The journal of allergy and clinical immunology. In practice · 2025
    Review
  6. Article
  7. Observational
  8. Article
  9. Article
  10. The Legacy of Redlining: Increasing Childhood Asthma Disparities through Neighborhood Poverty.American journal of respiratory and critical care medicine · 2024
    Article
  11. Review
  12. 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.American journal of respiratory and critical care medicine · 2024
    Article
  13. Article
  14. New Insights Relating Gasdermin B to the Onset of Childhood Asthma.American journal of respiratory cell and molecular biology · 2022
    Review
  15. Article
  16. Review
  17. Childhood Wheeze Patterns: What Do They Tell Us?American journal of respiratory and critical care medicine · 2022
    Article
  18. Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.American journal of respiratory and critical care medicine · 2022
    Article
  19. Sphingolipids and Asthma.Advances in experimental medicine and biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 12 institutions in 1 country.

Brian HallmarkAsthma and Airway Disease Research Center.
Ganesa WegienkaDepartment of Public Health Sciences, Henry Ford Hospital and Health System, Detroit, Michigan.
Suzanne HavstadDepartment of Public Health Sciences, Henry Ford Hospital and Health System, Detroit, Michigan.
Dean BillheimerBIO5 Institute.
Dennis OwnbyDepartment of Public Health Sciences, Henry Ford Hospital and Health System, Detroit, Michigan.
Eneida A MendoncaDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin.
Lisa GressDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Debra A SternAsthma and Airway Disease Research Center.
Jocelyn Biagini MyersDivision of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Gurjit K Khurana HersheyDivision of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Lori HoepnerDepartment of Environmental and Occupational Health Sciences, Downstate Health Sciences University School of Public Health, State University of New York, Brooklyn, New York.
Rachel L MillerDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Robert F LemanskeDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Daniel J JacksonDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Diane R GoldThe Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
George T O'ConnorDepartment of Pediatrics, Boston University, Boston, Massachusetts; and.
Dan L NicolaeDepartment of Human Genetics and.
James E GernDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.ORCID 0000-0002-6667-4708
Carole OberDepartment of Human Genetics and.
Anne L WrightAsthma and Airway Disease Research Center.
Fernando D MartinezAsthma and Airway Disease Research Center.
University of Wisconsin–Madison · USHenry Ford Health System · USCincinnati Children's Hospital Medical Center · USDermatology Research Center · USUniversity of Arizona · USBIO5 InstituteBoston University · USBrigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USRegenstrief Institute · USState University of New York · USUniversity of Chicago · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
ZIPRASIDONE (GEODON) AUGMENTATION IN SEROTONIN REUPTAKE INHIBITOR-RESISTANT OBM01RR000071 · NCRR · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GOODMAN, MARC T · 1985 to 2009
$41.5M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BOCHKOV, YURY A · 2002 to 2017
$31.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR002345NCRR NIH HHS M01 RR000052NCRR NIH HHS M01 RR000071NCRR NIH HHS M01 RR000533NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR024992NCRR NIH HHS UL1 RR025771NHLBI NIH HHS P01 HL070831NHLBI NIH HHS R01 HL056177NHLBI NIH HHS R01 HL132523NHLBI NIH HHS U10 HL064305NIAID NIH HHS HHSN272200900052CNIAID NIH HHS HHSN272201000052INIAID NIH HHS N01 AI025482NIAID NIH HHS N01 AI025496NIAID NIH HHS R01 AI035786NIAID NIH HHS UM1 AI114271NICHD NIH HHS R01 HD061879NIEHS NIH HHS P01 ES009600NIEHS NIH HHS P30 ES006694NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES008977NIEHS NIH HHS R01 ES011170NIEHS NIH HHS R01 ES013163NIEHS NIH HHS R01 ES019890NIH HHS UG3 OD023282NIH HHS UG3 OD023290NIH HHS UH3 OD023282NIH HHS UH3 OD023290NIMH NIH HHS R01 MH061879
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chromosomes, Human, Pair 17Genetic VariationPhenotypeAge FactorsAsthmaBlack or African AmericanChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornLatent Class AnalysisMaleRespiratory Sounds17q12-21asthmageneticslatent class analysiswheeze

Identifiers

PMID33535024
PMCPMC8017591
OpenAlexW3129088312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.