ArticleAmerican journal of epidemiology2021
Adverse Childhood Experiences and Rate of Memory Decline From Mid to Later Life: Evidence From the English Longitudinal Study of Ageing.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- "We adjusted for race": now what? A systematic review of utilization and reporting of race in American Journal of Epidemiology and Epidemiology, 2020-2021.Epidemiologic reviews · 2023Pooled it
- The association of adverse childhood experiences and life course relationship quality with late-life cognitive health: Moderation by race/ethnicity and gender.Journal of Alzheimer's disease : JAD · 2026Article
- Association of Adverse Childhood Experiences and Cognitive Health in Older Adults: Rush Memory and Aging Project.The American journal of geriatric psychiatry. Open science, education, and practice · 2026Article
- Sex differences in the association of adverse childhood experiences with brain and cognition along a continuum of risk for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Associations between life-course cognitive reserve and cognitive domains over 8 years in a large cohort of middle-aged and older adults: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Longitudinal influences of adverse childhood experience patterns on mental health among older Chinese people.BMC geriatrics · 2025Article
- Early-Life Adversity Predicts Markers of Aging-Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women.Annals of neurology · 2025Article
- The link between traumatic experiences and health in late life: challenges and opportunities for US-based longitudinal aging cohorts.American journal of epidemiology · 2025Article
- Sex Differences in the Associations Among Early Life Adversity, Inflammation, and Cognition.Biomolecules · 2025Review
- Adverse childhood experiences and chronic pain in adults aged 86: findings from the Lothian Birth Cohort 1936.Frontiers in aging · 2025Article
- Childhood adversity and late-life cognitive and brain health in a diverse cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Adverse childhood experiences, marital status and depressive symptoms in later life among the Chinese middle-aged and older adults : the mediating role of marital status.BMC public health · 2024Article
- Adverse Childhood Experiences and Later-Life Cognitive Aging: Persistent Methodological Challenges Limit the Evidence Base.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Allostasis, health, and development in Latin America.Neuroscience and biobehavioral reviews · 2024Review
- Lifetime adversity predicts depression, anxiety, and cognitive impairment in a nationally representative sample of older adults in the United States.Journal of clinical psychology · 2024Article
- Time-lagged associations between two adverse childhood experiences and later-life cognitive function through educational attainment and stroke.Journal of the International Neuropsychological Society : JINS · 2024Article
- Longitudinal association of adverse childhood experiences with cognitive function trajectories among middle-aged and older adults: group-based trajectory modeling.Frontiers in psychiatry · 2024Article
- Exposure to Adversity and its Impact on Later Life Cognitive, Mental, and Physical Health.International journal of public health · 2024Article
- Adverse childhood experiences and cognitive function in later life: the sequential mediating roles of education level and adult loneliness.Frontiers in public health · 2024Article
- Inflammation and olfactory loss are associated with at least 139 medical conditions.Frontiers in molecular neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Evidence on the role of early-life adversity in later-life memory decline is conflicting. We investigated the relationships between adverse childhood experiences (ACEs) and memory performance and rate of decline over a 10-year follow-up among middle-aged and older adults in England. Data were from biennial interviews with 5,223 participants aged 54 years or older in the population-representative English Longitudinal Study of Ageing from 2006/2007 to 2016/2017. We examined self-reports of 9 ACEs prior to age 16 years that related to abuse, household dysfunction, and separation from family. Memory was assessed at each time point as immediate and delayed recall of 10 words. Using linear mixed-effects models with person-specific random intercepts and slopes and adjusted for baseline age, participants' baseline age squared, sex, ethnicity, and childhood socioeconomic factors, we observed that most individual and cumulative ACE exposures had null to weakly negative associations with memory function and rate of decline over the 10-year follow-up. Having lived in residential or foster care was associated with lower baseline memory (adjusted β = -0.124 standard deviation units; 95% confidence interval: -0.273, -0.025) but not memory decline. Our findings suggest potential long-term impacts of residential or foster care on memory and highlight the need for accurate and detailed exposure measures when studying ACEs in relation to later-life cognitive outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.