ArticleAmerican journal of epidemiology2021
Trends in Frailty and Its Association With Mortality: Results From the Longitudinal Aging Study Amsterdam, 1995-2016.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The relationship between frailty status and psychosocial indices in older Korean adults.GeroScience · 2026Article
- Frailty among older adults in Germany: regional variation across NAKO study centers.International journal for equity in health · 2026Article
- AI-driven scientometric analysis with recency insights: lower urinary tract symptoms in older and frail populations.World journal of urology · 2025Article
- Deep learning-quantified body composition from positron emission tomography/computed tomography and cardiovascular outcomes: a multicentre study.European heart journal · 2025Article
- The Longitudinal Aging Study Amsterdam: design and cohort update 2025.European journal of epidemiology · 2025Article
- Health octo tool matches personalized health with rate of aging.Nature communications · 2025Article
- Frailty and loneliness among community-dwelling older adults: examining reciprocal associations within a measurement burst design.BMC geriatrics · 2025Article
- Associations Between Frailty and Risk of All-Cause and Cardiovascular Mortality in Patients with Prediabetes: A Population-Based Study.Journal of multidisciplinary healthcare · 2025Article
- Article
- The association between continuing work after retirement and the incidence of frailty: evidence from the China health and retirement longitudinal study.The journal of nutrition, health & aging · 2024Article
- The Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation: A Nationwide Population Study.JACC. Advances · 2024Article
- A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based study.The Korean journal of internal medicine · 2024Article
- Early Origins of Frailty: Do Later-Life Social Relationships Alter Trajectories of Decline?Journal of aging and health · 2024Article
- Frailty, but not cognitive impairment, improves mortality risk prediction among those with chronic kidney disease-a nationally representative study.BMC nephrology · 2024Article
- Longitudinal Quantiles of Frailty Trajectories Considering Death: New Insights into Sex and Cohort Differences in the Reference Curves for Frailty Progression of Older European.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Reliability of the Frailty Index Among Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Frailty before and during austerity: A time series analysis of the English Longitudinal Study of Ageing 2002-2018.PloS one · 2024Article
- Living Longer But Frailer? Temporal Trends in Life Expectancy and Frailty in Older Swedish Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Trends in Frailty Prevalence Among Older Adults in Korea: A Nationwide Study From 2008 to 2020.Journal of Korean medical science · 2023Article
- Relationship of frailty status with health resource use and healthcare costs in the population aged 65 and over in Catalonia.European journal of ageing · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
The aim of this study was to investigate trends in frailty and its relationship with mortality among older adults aged 64-84 years across a period of 21 years. We used data from 1995 to 2016 from the Longitudinal Aging Study Amsterdam. A total of 7,742 observations of 2,874 respondents in the same age range (64-84 years) across 6 measurement waves were included. Frailty was measured with a 32-item frailty index, with a cutpoint of ≥0.25 to indicate frailty. The outcome measure was 4-year mortality. Generalized estimating equation analyses showed that among older adults aged 64-84 years the 4-year mortality rate declined between 1995 and 2016, while the prevalence of frailty increased. Across all measurement waves, frailty was associated with 4-year mortality (odds ratio = 2.79, 95% confidence interval: 2.39, 3.26). There was no statistically significant interaction effect between frailty and time on 4-year mortality, indicating a stable association between frailty and mortality. In more recent generations of older adults, frailty prevalence rates were higher, while excess mortality rates of frailty remained the same. This is important information for health policy-makers and clinical practitioners, showing that continued efforts are needed to reduce frailty and its negative health consequences.
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