Evidence map›Paper›PMID 33534213›Full record

ArticleThe American Journal of dermatopathology2021

Pure and Mixed Desmoplastic Melanomas: A Retrospective Clinicopathologic Comparison of 33 Cases.

Sherman Chu, Kory P Schrom, Raghav Tripathi, Rosalynn R Z Conic, Harib H Ezaldein, Jeffrey F Scott, Kord Honda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American Journal of dermatopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sherman ChuDepartment of Dermatology, Case Western Reserve University, Cleveland, OH.
Kory P SchromDepartment of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH.
Raghav TripathiDepartment of Dermatology, Case Western Reserve University, Cleveland, OH.
Rosalynn R Z ConicDepartment of Family and Preventive Medicine, University of California San Diego, San Diego, CA; and.
Harib H EzaldeinDepartment of Dermatology, Case Western Reserve University, Cleveland, OH.
Jeffrey F ScottDepartment of Dermatology, Case Western Reserve University, Cleveland, OH.
Kord HondaDepartment of Dermatology, Case Western Reserve University, Cleveland, OH.
Case Western Reserve University · USPacific Northwest University of Health Sciences · USUniversity Hospitals of Cleveland · USUniversity of California, San Diego · US

Funding

TRAINING IN INVESTIGATIVE AND MOLECULAR DERMATOLOGYT32AR007569 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1991 to 2019
$2.7M
NIAMS NIH HHS T32 AR007569
6 · The paper itself

Abstract

backgroundPure and mixed desmoplastic melanomas (DMs) may have different natural histories and behaviors.

methodsWe conducted a retrospective review of patients diagnosed with DM at our institution between January 1997 and April 2019. A total of 33 unique DMs were identified and subsequently analyzed based on the histologic type (pure vs. mixed).

resultsThe majority (57.6%) of our cases were classified as pure histology. Patients with pure DMs were more likely to be men (P = 0.035) and be older than 65 years (P = 0.019) compared with patients with mixed DMs. Patients with mixed DM were more likely to have mitoses present (P = 0.001) compared with patients with pure DM. There were no differences in ulceration, perineural invasion, vascular invasion, or survival between patients with pure and mixed histologic subtypes. In addition, no differences in sentinel lymph node biopsy, radiation, or chemotherapy were noted between the 2 histologic subtypes. Immunohistochemistry showed that 27.3% of the pure DMs stained with Melan-A and HMB45 were positive for these immunomarkers.

conclusionsPure and mixed variants of DM were found to have similar clinicopathologic characteristics. Patients with the mixed histologic subtype were more likely to have mitoses, but no difference in the therapeutic management or patient survival was seen between the 2 subtypes.

Indexed as

AdultAgedAged, 80 and overFemaleHead and Neck NeoplasmsHumansImmunohistochemistryMaleMART-1 AntigenMelanomaMiddle AgedMitosisRetrospective StudiesSkin NeoplasmsSurvival RateMART-1 AntigenMLANA protein, human

Identifiers

PMID33534213
PMCPMC8310890
OpenAlexW3127695355

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.