ArticlePharmacoepidemiology and drug safety2021
Trends in fall-related mortality and fall risk increasing drugs among older individuals in the United States,1999-2017.
Article in Pharmacoepidemiology and drug safety, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effectiveness of clinical decision support in fall prevention among older adults: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Impact of medication therapy management programs on potentially inappropriate medication use in older adults: A systematic review.Journal of managed care & specialty pharmacy · 2024Pooled it
- A systematic review of chiropractic care for fall prevention: rationale, state of the evidence, and recommendations for future research.BMC musculoskeletal disorders · 2022Pooled it
- Updating the potentially inappropriate medication (PIM)-China criteria for 2024: a Delphi consensus study for improved medication safety in older adults.International journal of clinical pharmacy · 2026Article
- Pharmacogenomic Drug-Gene Interactions in Geriatric Emergency Department Patients Who Sustained Falls: A Pilot Study.The western journal of emergency medicine · 2025Article
- Drug-related falls: proportion and impact of hospitalizations in geriatric departments on the prescription of fall-risk increasing drugs (FRIDs).European journal of clinical pharmacology · 2025Observational
- Assessing Older Adults' Readiness for Adopting Fall Prevention Recommendations Using the Transtheoretical Stages of Change.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Racial and Ethnic Differences in Potentially Inappropriate Medication Use Among Medicare Beneficiaries.JAMA network open · 2025Article
- Evaluation of content validity and feasibility of the World Falls Guidelines' three key questions to identify falls among older adult users of home care services in Norway.BMC health services research · 2025Article
- Remote monitoring of Tai Chi balance training interventions in older adults using wearable sensors and machine learning.Scientific reports · 2025Article
- Consumer Products Nerve Injuries Among Patients Products Presenting to United States Emergency Departments Between 2012 and 2021: A Nationwide Cohort.Open access emergency medicine : OAEM · 2025Article
- Remote Monitoring of Tai Chi Balance Training Interventions in Older Adults Using Wearable Sensors and Machine Learning.Research square · 2024Article
- Factors associated with fall risk increasing drug use in older black and white men and women: the Health ABC Study.BMC geriatrics · 2024Article
- Impact of comprehensive medication reviews on potentially inappropriate medication discontinuation in Medicare beneficiaries.Journal of the American Geriatrics Society · 2024Article
- Combined effect of falling difficulty and cardiovascular diseases on the risk of all-cause and cardiovascular mortality in older adults: an analysis of the National Health and Nutrition Examination Survey.European geriatric medicine · 2024Article
- Potentially Inappropriate Medications in Hospitalized Older Patients in Tabuk, Saudi Arabia Using 2023 Beers Criteria: A Retrospective Multi-Centric Study.Journal of multidisciplinary healthcare · 2024Article
- Retrospective Investigation and Research on Fall Events Among Hospitalized Patients in the Rehabilitation Department.Risk management and healthcare policy · 2024Article
- Association of diuretics with falls and wrist fractures: a Mendelian randomization study.Frontiers in public health · 2024Article
- Considering pharmacoequity when deprescribing potentially inappropriate medications.Journal of the American Geriatrics Society · 2023Article
- One-Legged Balance Performance and Fall Risk in Mid and Later Life: Longitudinal Evidence From a British Birth Cohort.American journal of preventive medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies have demonstrated increasing mortality due to falls among older adults. The objective of this study was to determine whether there was an increase in fall risk increasing drug prescribing and if this is concurrent with an increase in fall-related mortality in persons 65 years and older in the United States.
methodsThe study is a serial cross-sectional analysis utilizing data from both the National Vital Statistics System (NVSS) and the medical expenditure panel survey (MEPS) for years 1999-2017. Adults aged 65 years and older were evaluated for death due to falls from the NVSS and for prescription fills of fall risk increasing drugs per the Stopping Elderly Accidents, Deaths, and Injuries-Rx (STEADI-Rx) fall checklist from the MEPS.
resultsThe analysis included 374 972 fall-related mortalities and 7 858 177 122 fills of fall risk increasing drugs. 563 037 964 persons age 65 and older received at least one fall risk increasing drug. Age-adjusted mortality due to falls increased from 29.40 per 100 000 in 1999 to 63.27 per 100 000 in 2017. The percent of persons who received at least one prescription for a fall risk increasing drug increased from 57% in 1999 to 94% in 2017 (p for trend <.0001). CONCLUSIONS AND RELEVANCE: Both use of fall risk increasing drugs and mortality due to falls are on the rise. Fall risk increasing drugs may partially explain the increase in mortality due to falls; this cannot be firmly concluded from the current study. Future research examining the potential relationship between fall risk increasing drugs and fall-related mortality utilizing nationally representative person-level data are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.