Evidence map›Paper›PMID 33534126›Full record

ArticleNeurotoxicity research2021

Naringin Exhibits Mas Receptor-Mediated Neuroprotection Against Amyloid Beta-Induced Cognitive Deficits and Mitochondrial Toxicity in Rat Brain.

Vibhav Varshney, Debapriya Garabadu

Abstract read
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In one paragraph

Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vibhav VarshneyDivision of Pharmacology, Institute of Pharmaceutical Research, GLA University, 281 406, Mathura, India.
Debapriya GarabaduDivision of Pharmacology, Institute of Pharmaceutical Research, GLA University, 281 406, Mathura, India. debapriya.garabadu@gla.ac.in.ORCID http://orcid.org/0000-0002-4235-3926
GLA University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with clinical manifestation of loss in cognitive functions in an individual. Though several drug candidates have been developed in the management of AD, an alternative option is still required due to serious adverse effects of the former. Recently, naringin exerts therapeutic benefits through rennin angiotensin system in experimental animals. However, its report  on Mas receptor-mediated action against amyloid beta (Aβ)-induced mitochondrial dysfunction in AD-like animals is lacking. The experimental dementia was induced in the male rats by intracerebroventricular administration of Aβ

Indexed as

Amyloid beta-PeptidesAngiotensin IIAnimalsBrainCognitive DysfunctionFlavanonesInfusions, IntraventricularMaleMaze LearningMitochondriaNeuroprotectionPeptide FragmentsRatsRats, Wistar7-Ala-angiotensin (1-7)Amyloid beta-Peptidesamyloid beta-protein (1-42)Angiotensin IIFlavanonesnaringinPeptide FragmentsAlzheimer’s diseaseAmygdaleAmyloid betaHippocampusMitochondriaPrefrontal cortex

Identifiers

PMID33534126
OpenAlexW3126500731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.